克氏锥虫前鞭毛体中吩嗪硫酸甲酯产生自由基的过程。
Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes.
作者信息
Docampo R, Cruz F S, Muniz R P, Esquivel D M, de Vasconcellos M E
出版信息
Acta Trop. 1978 Sep;35(3):221-37.
PMID:31775
Abstract
A significant growth inhibition of Trypanosoma cruzi epimastigotes by phenazine methosulfate (PMS) was observed in Warren's medium. This toxic activity could be related to the following parameters: a) formation of phenazinium free radical, b) generation of superoxide anion in intact cells incubated with PMS, and c) PMS also increased significantly the rate of O2- generation in epimastigotes mitochondrial and microsomal fractions using NADH as electron donor.
摘要
在沃伦培养基中观察到硫酸吩嗪（PMS）对克氏锥虫前鞭毛体有显著的生长抑制作用。这种毒性活性可能与以下参数有关：a）吩嗪鎓自由基的形成；b）用PMS孵育的完整细胞中超氧阴离子的产生；c）以NADH作为电子供体时，PMS还显著提高了前鞭毛体线粒体和微粒体组分中O2-的产生速率。
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