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用阳离子电子载体处理感染的巨噬细胞后，细胞内克氏锥虫被破坏。

Destruction of intracellular Trypanosoma cruzi after treatment of infected macrophages with cationic electron carriers.

作者信息

Alves M J, Rabinovitch M

出版信息

Infect Immun. 1983 Jan;39(1):435-8. doi: 10.1128/iai.39.1.435-438.1983.

DOI:10.1128/iai.39.1.435-438.1983
PMID:6337104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC347957/
Abstract

Intracellular forms of Trypanosoma cruzi were destroyed in infected mouse macrophage cultures treated for 24 h with micromolar concentrations of phenazine methosulfate, brilliant cresyl blue, or crystal violet. Parasites were not killed in macrophages which were only treated with the dyes before infection, indicating that the drugs did not induce a protracted state of macrophage trypanocidal activity.

摘要

在用微摩尔浓度的吩嗪硫酸甲酯、灿烂甲酚蓝或结晶紫处理24小时的感染小鼠巨噬细胞培养物中，克氏锥虫的细胞内形式被破坏。在感染前仅用染料处理的巨噬细胞中，寄生虫未被杀死，这表明这些药物不会诱导巨噬细胞产生持久的杀锥虫活性状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69e1/347957/e4033c712c34/iai00142-0455-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69e1/347957/e4033c712c34/iai00142-0455-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69e1/347957/e4033c712c34/iai00142-0455-a.jpg

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本文引用的文献

1
GROWTH AND DIFFERENTIATION IN TRYPANOSOMA CRUZI. I. ORIGIN OF METACYCLIC TRYPANOSOMES IN LIQUID MEDIA.克氏锥虫的生长与分化。一、液体培养基中循环后期锥虫的起源
Rev Inst Med Trop Sao Paulo. 1964 May-Jun;6:93-100.
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[Effect of triphenylmethane dyes on Trypanosoma cruzi in vitro; use of gentian violet in prevention of transmission of Chagas disease by blood transfusion].[三苯甲烷染料对克氏锥虫的体外作用；龙胆紫在预防输血传播恰加斯病中的应用]
Hospital (Rio J). 1953 Dec;44(6):731-44.
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Destruction of Leishmania mexicana amazonensis amastigotes within macrophages in culture by phenazine methosulfate and other electron carriers.
吩嗪硫酸甲酯和其他电子载体对培养的巨噬细胞内墨西哥利什曼原虫亚马逊亚种无鞭毛体的破坏作用
J Exp Med. 1982 Feb 1;155(2):415-31. doi: 10.1084/jem.155.2.415.
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Leishmania donovani, Plasmodium berghei, Trypanosoma rhodesiense: antiprotozoal effects of some amidine types.杜氏利什曼原虫、伯氏疟原虫、罗德西亚锥虫：某些脒类的抗原虫作用。
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Induction of plasminogen activator secretion in macrophages by electrochemical stimulation of the hexose monophosphate shunt with methylene blue.用亚甲蓝对己糖磷酸旁路进行电化学刺激诱导巨噬细胞分泌纤溶酶原激活物。
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Mechanisms of intracellular protein breakdown.细胞内蛋白质降解的机制。
Annu Rev Biochem. 1982;51:335-64. doi: 10.1146/annurev.bi.51.070182.002003.
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Active oxygen species and the functions of phagocytic leukocytes.活性氧物质与吞噬性白细胞的功能
Annu Rev Biochem. 1980;49:695-726. doi: 10.1146/annurev.bi.49.070180.003403.
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Interaction of the 5-methylphenazinium cation radical with deoxyribonucleic acid.5-甲基吩嗪鎓阳离子自由基与脱氧核糖核酸的相互作用
Biochemistry. 1969 Mar;8(3):1238-46. doi: 10.1021/bi00831a059.