Chen K W, Tong Y L, Yao Y M
Trauma Research Center, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
Department of Burns and Plastic Surgery, the 181st Hospital of PLA, Guilin 541002, China.
Zhonghua Shao Shang Za Zhi. 2019 Nov 20;35(11):828-832. doi: 10.3760/cma.j.issn.1009-2587.2019.11.013.
The repair strategy after organs injuries has always been a hot topic in the field of regenerative medicine. Traditional injury repair measures mainly promote tissue repair through mesenchymal stem cells and various growth factors, but these strategies have been constrained in the aspects of security and economy. Hence, there is an urgent need to find new ways to promote tissue repair and regeneration. There have been a lot of evidences showing that the immune system plays an important role in tissue regeneration and repair. In recent years, more and more studies have been done on adaptive immunity in tissue repair, especially the regulatory T cells. Some evidences indicate that regulatory T cells participate in damage tissue repair and regeneration of multiple organs and tissue. This review briefly introduces the new advances in the repair effects and regulatory mechanism of regulatory T cells in different organ injuries, in order to provide new ideas for designing advanced repair materials with good immunoregulatory functions.
器官损伤后的修复策略一直是再生医学领域的热点话题。传统的损伤修复措施主要通过间充质干细胞和各种生长因子促进组织修复，但这些策略在安全性和经济性方面受到限制。因此，迫切需要寻找促进组织修复和再生的新方法。有大量证据表明，免疫系统在组织再生和修复中发挥着重要作用。近年来，关于组织修复中适应性免疫的研究越来越多，尤其是调节性T细胞。一些证据表明，调节性T细胞参与多种器官和组织的损伤组织修复和再生。本文综述简要介绍了调节性T细胞在不同器官损伤中的修复作用和调节机制的新进展，以期为设计具有良好免疫调节功能的先进修复材料提供新思路。
