Department of Surgery, Innlandet Hospital Trust, Gjøvik, Norway.
Department of Medicine and Geriatrics, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Sci Rep. 2019 Nov 27;9(1):17695. doi: 10.1038/s41598-019-54107-z.
C-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these biomarkers after conservative and surgical weight loss interventions in individuals with morbid obesity, to evaluate associations between biomarker changes and changes in body mass index and HbA1c, and to study associations between changes in the biomarkers. C-reactive protein, neopterin and lactoferrin were measured before and after conservative weight loss intervention and bariatric surgery. Data were analysed with mixed models. 137 individuals (mean age 43 years) were included. Body mass index decreased from 42.1 kg/m to 38.9 kg/m after the conservative intervention, and further to 30.5 kg/m after bariatric surgery. All biomarkers decreased after the conservative weight loss intervention. C-reactive protein and lactoferrin continued to decrease following bariatric surgery whereas neopterin remained stable. After adjustments for change in body mass index and HbA1c, all biomarkers decreased significantly after the conservative weight loss intervention, whereas none changed after bariatric surgery. There were no consistent correlations between changes in C-reactive protein, neopterin and lactoferrin. In conclusion, biomarkers of atherosclerosis decreased after weight loss interventions but had different trajectories. Neopterin, a marker related to atherosclerotic plaque stability, decreased after conservative weight loss but not following bariatric surgery.
C 反应蛋白、新蝶呤和乳铁蛋白是动脉粥样硬化疾病的生物标志物。我们旨在评估病态肥胖个体接受保守和手术减肥干预后这些生物标志物的变化，评估生物标志物变化与体重指数和 HbA1c 变化之间的关系，并研究生物标志物之间的变化关系。在保守减肥干预和减肥手术后测量 C 反应蛋白、新蝶呤和乳铁蛋白。使用混合模型分析数据。纳入了 137 名（平均年龄 43 岁）个体。体重指数从 42.1kg/m 下降到保守干预后的 38.9kg/m，进一步下降到减肥手术后的 30.5kg/m。所有生物标志物在保守减肥干预后均下降。C 反应蛋白和乳铁蛋白在减肥手术后继续下降，而新蝶呤保持稳定。在调整体重指数和 HbA1c 的变化后，保守减肥干预后所有生物标志物均显著下降，而减肥手术后无变化。C 反应蛋白、新蝶呤和乳铁蛋白之间没有一致的相关性。总之，动脉粥样硬化的生物标志物在减肥干预后下降，但轨迹不同。与动脉粥样硬化斑块稳定性相关的标志物新蝶呤在保守减肥后下降，但在减肥手术后没有下降。
