Department of Research, Innlandet Hospital Trust, N-2381 Brumunddal, Norway.
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.
Nutrients. 2020 Mar 18;12(3):802. doi: 10.3390/nu12030802.
The gut microbiota and their metabolites, e.g., short-chain fatty acids (SCFA), are associated with obesity. The primary aims were to study faecal SCFA levels and the changes in SCFA levels after weight-loss interventions in subjects with obesity, and secondarily, to study factors associated with the faecal SCFA levels. In total, 90 subjects (men / women: 15/75) with a mean age of 44.4 (SD 8.4) years, BMI 41.7 (SD 3.7) kg/m and morbid obesity (BMI > 40 or > 35 kg/m with obesity-related complications) were included. Faecal SCFA and other variables were measured at inclusion and after a six-month conservative weight-loss intervention followed by bariatric surgery (RouxenY gastric bypass or gastric sleeve). Six months after surgery, the total amount of SCFA was reduced, the total and relative amounts of the main straight SCFA (acetic-, propionic-, and butyric- acids) were reduced, and the total and relative amounts of branched SCFA (isobutyric-, isovaleric-, and isocaproic- acids) were increased. The changes indicate a shift toward a proteolytic fermentation pattern with unfavorable health effects. The amount of SCFA was associated with the diet but not with metabolic markers or makers of the faecal microbiota composition. Dietary interventions could counteract the unfavorable effects.
肠道微生物群及其代谢产物，例如短链脂肪酸（SCFA），与肥胖有关。主要目的是研究肥胖患者粪便中 SCFA 水平以及减肥干预后 SCFA 水平的变化，其次是研究与粪便 SCFA 水平相关的因素。共纳入 90 名受试者（男性/女性：15/75），平均年龄 44.4（SD 8.4）岁，BMI 41.7（SD 3.7）kg/m2 和病态肥胖（BMI>40 或>35 kg/m2 伴有肥胖相关并发症）。在纳入时和 6 个月的保守减肥干预后（随后进行减肥手术（RouxenY 胃旁路或胃袖状切除术））测量粪便 SCFA 和其他变量。手术后 6 个月，SCFA 的总量减少，主要直链 SCFA（乙酸、丙酸和丁酸）的总量和相对量减少，支链 SCFA（异丁酸、异戊酸和异己酸）的总量和相对量增加。这些变化表明，发酵模式向蛋白水解发酵模式转变，对健康产生不利影响。SCFA 的含量与饮食有关，但与代谢标志物或粪便微生物群组成标志物无关。饮食干预可能会抵消不利影响。
