灵芝对心血管系统的保护作用。

Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System.

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.

Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.

出版信息

Adv Exp Med Biol. 2019;1182:181-199. doi: 10.1007/978-981-32-9421-9_7.

DOI:10.1007/978-981-32-9421-9_7

PMID:31777019

Abstract

Cardiovascular diseases (CVDs) are disorders of the heart and blood vessels and include coronary heart diseases, cerebrovascular diseases, rheumatic heart diseases, and other conditions. CVDs are one of the most major causes of morbidity and mortality around the world, taking the lives of 17.9 million people every year. Several investigations have shown the influence of Ganoderma lucidum (G. lucidum, Lingzhi) on some metabolic markers, such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), blood pressure, and oxidative damage. G. lucidum potentially reduces the risk of suffering cardiovascular diseases. Some studies found that G. lucidum prevented from heart damage in a variety of disease models, such as streptozotocin (STZ)-induced diabetic, high-fat-diet-induced diabetic, isoprenaline (ISO)-induced myocardial hypertrophy, acute ethanol-induced heart toxicity, and transverse aortic constriction (TAC) models. This chapter summarizes putative preventive and therapeutic effects of G. lucidum on cardiovascular diseases and the potential clinical use of G. lucidum involved in these effects.

摘要

心血管疾病（CVDs）是指心脏和血管的疾病，包括冠心病、脑血管疾病、风湿性心脏病等。CVDs 是全球发病率和死亡率的主要原因之一，每年导致 1790 万人死亡。多项研究表明，灵芝（Ganoderma lucidum，Lingzhi）对一些代谢标志物如低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总胆固醇（TC）、血压和氧化损伤有影响。灵芝可能降低患心血管疾病的风险。一些研究发现，灵芝在各种疾病模型中预防心脏损伤，如链脲佐菌素（STZ）诱导的糖尿病、高脂肪饮食诱导的糖尿病、异丙肾上腺素（ISO）诱导的心肌肥厚、急性乙醇诱导的心脏毒性和主动脉缩窄（TAC）模型。本章总结了灵芝对心血管疾病的潜在预防和治疗作用，以及灵芝在这些作用中的潜在临床应用。