Teseo Serafino, Houot Benjamin, Yang Kaiye, Monnier Véronique, Liu Guangrong, Tricoire Hervé
1Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France.
2School of Biological Sciences, Nanyang Technological University, Singapore.
Aging Dis. 2021 Apr 1;12(2):425-440. doi: 10.14336/AD.2020.0714-1. eCollection 2021 Apr.
In the last decades, the strong increase in the proportion of older people worldwide, and the increased prevalence of age associated degenerative diseases, have put a stronger focus on aging biology. In spite of important progresses in our understanding of the aging process, an integrative view is still lacking and there is still need for efficient anti-aging interventions that could improve healthspan, reduce incidence of age-related disease and, eventually, increase the lifespan. Interestingly, some compounds from traditional medicine have been found to possess anti-oxidative and anti-inflammatory properties, suggesting that they could play a role as anti-aging compounds, although in depth investigations are still scarce. In this study we used one the major aging model organisms, to investigate the ability of four herb extracts (HEs: , , and ) widely used in traditional Chinese medicine (TCM) to slow down aging and improve healthspan of aged animals. Combining multiple approaches (stress resistance assays, lifespan and metabolic measurements, functional heart characterizations and behavioral assays), we show that these four HEs provide protection from various insults, albeit with significant compound-specific differences. Importantly, extracts of and increase the healthspan of aging animals, as shown by increased activity during aging and improved heart function. In addition, these two compounds also provide protection in a Drosophila model of Huntington's disease (HD), suggesting that, besides their anti-aging properties in normal individuals, they could be also efficient in the protection against age-related diseases.
在过去几十年中，全球老年人比例的大幅上升以及与年龄相关的退行性疾病患病率的增加，使得衰老生物学受到了更多关注。尽管我们对衰老过程的理解取得了重要进展，但仍缺乏综合观点，仍然需要有效的抗衰老干预措施来改善健康寿命、降低与年龄相关疾病的发病率，并最终延长寿命。有趣的是，已发现一些传统药物中的化合物具有抗氧化和抗炎特性，这表明它们可能作为抗衰老化合物发挥作用，尽管深入研究仍然很少。在本研究中，我们使用一种主要的衰老模式生物，来研究四种广泛应用于中医的草药提取物（HEs：[具体提取物名称1]、[具体提取物名称2]、[具体提取物名称3]和[具体提取物名称4]）延缓衰老和改善老年动物健康寿命的能力。通过结合多种方法（抗应激试验、寿命和代谢测量、心脏功能表征和行为试验），我们表明这四种HEs能提供针对各种损伤的保护，尽管存在显著的化合物特异性差异。重要的是，[具体提取物名称1]和[具体提取物名称2]的提取物可延长衰老动物的健康寿命，这表现为衰老过程中活动增加和心脏功能改善。此外，这两种化合物在亨廷顿舞蹈病（HD）的果蝇模型中也提供保护，这表明，除了在正常个体中的抗衰老特性外，它们在预防与年龄相关疾病方面也可能有效。
