皮肤血流对局部应用烟碱酸甲酯的反应：可能的机制。
Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms.
机构信息
Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Department of Plastic Surgery, Hand Surgery, and Burns, Linköping University, Linköping, Sweden.
出版信息
Skin Res Technol. 2020 May;26(3):343-348. doi: 10.1111/srt.12807. Epub 2019 Nov 27.
BACKGROUND
Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin-mediated pathways.
METHODS
MN was applied on the skin of healthy subjects in which NO-mediated (L-NMMA), nerve-mediated (lidocaine/prilocaine), and cyclooxygenase-mediated (NSAID) pathways were selectively inhibited. Microvascular responses in the skin were measured using laser speckle contrast imaging (LSCI).
RESULTS
NSAID reduced the MN-induced perfusion increase with 82% (P < .01), whereas lidocaine/prilocaine reduced it with 32% (P < .01). L-NMMA did not affect the microvascular response to MN.
CONCLUSION
The prostaglandin pathway and local sensory nerves are involved in the vasodilatory actions of MN in the skin.
背景
烟碱酸甲酯（MN）可引起皮肤局部红斑，因此可能对评估微循环和皮肤活力有一定价值。MN 介导其血管作用的机制尚不完全清楚。本研究旨在描述局部应用 MN 的血管舒张作用，并研究一氧化氮（NO）、局部感觉神经和前列腺素介导的途径的参与。
方法
在健康受试者的皮肤上应用 MN，选择性抑制 NO 介导（L-NMMA）、神经介导（利多卡因/丙胺卡因）和环氧化酶介导（NSAID）途径。使用激光散斑对比成像（LSCI）测量皮肤中的微血管反应。
结果
NSAID 使 MN 引起的灌注增加减少了 82%（P <.01），而利多卡因/丙胺卡因使灌注增加减少了 32%（P <.01）。L-NMMA 对 MN 引起的微血管反应没有影响。
结论
前列腺素途径和局部感觉神经参与了 MN 在皮肤中的血管舒张作用。
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