皮肤表面涂抹烟碱酸甲酯后的微血管反应：浓度与皮肤部位差异的影响。

The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites.

机构信息

Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Plastic Surgery, Hand Surgery, and Burns, Linköping University, Linköping, Sweden.

Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.

出版信息

Microvasc Res. 2019 Jul;124:54-60. doi: 10.1016/j.mvr.2019.03.002. Epub 2019 Mar 12.

DOI:10.1016/j.mvr.2019.03.002

PMID:30877017

Abstract

BACKGROUND

Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be used as a local provocation in the assessment of microcirculation and skin viability. The aims were to measure the effects of increasing doses of MN, to find the concentration that yields the most reproducible effect from day to day and between sites, and to study the variation between skin sites.

METHODS

Microvascular responses to topically applied MN at different concentrations were measured in 12 subjects on separate days and on contralateral sides, using laser speckle contrast imaging (LSCI). MN effects were measured in four different body sites.

RESULTS

At 20 mmol/L, the response to MN was most reproducible day-to-day and site-to-site, and resulted in a plateau response between 5 and 20 min after application. The skin region of the lower back had a lower perfusion value compared to the epigastric region (p = 0.007). When responses were compared to nearby, unprovoked areas, a significantly larger increase in perfusion was seen in the forearm, compared to all other anatomical sites (p < 0.03).

CONCLUSION

A concentration of 20 mmol/L MN generated the most reproducible microvascular response in the skin. The response varies between different body sites.

摘要

背景

烟碱酸甲酯（MN）会引起皮肤局部红斑，可用于评估微循环和皮肤活力的局部激发。目的是测量增加剂量的 MN 的效果，找到每天和不同部位之间最具可重复性的效果的浓度，并研究皮肤部位之间的差异。

方法

使用激光散斑对比成像（LSCI）在不同日子和对侧部位测量 12 名受试者局部应用不同浓度 MN 的微血管反应。MN 作用在四个不同的身体部位进行测量。

结果

在 20mmol/L 时，MN 的反应最具可重复性，每天和每个部位之间的反应都很稳定，并且在应用后 5 至 20 分钟之间产生了平台反应。下背部的皮肤区域与上腹部区域相比，灌注值较低（p=0.007）。当将反应与附近未受刺激的区域进行比较时，与所有其他解剖部位相比，前臂的灌注增加明显更大（p<0.03）。