Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Neurocase. 2020 Feb;26(1):60-63. doi: 10.1080/13554794.2019.1697823. Epub 2019 Nov 28.
We experienced a case of very early-onset REM sleep behavior disorder (RBD) with ADHD. This case showed typical RBD symptoms with REM sleep without atonia on polysomnography. Methylphenidate, which enhances the dopamine system, attenuated his ADHD symptoms but not RBD symptoms. We speculate that the dysfunction of the laterodorsal tegmental nucleus in the pontine was responsible for the symptoms of RBD and ADHD in this case. Very early-onset RBD is rare, and its profile is not well known. ADHD with dysfunction in the laterodorsal tegmental nucleus may form asubtype of ADHD that is commonly comorbid with very early-onset RBD.
我们遇到了一例极早发性 REM 睡眠行为障碍（RBD）合并 ADHD。该病例在多导睡眠图上表现出典型的 RBD 症状，即 REM 睡眠无去动停止。哌甲酯可增强多巴胺系统，能减轻他的 ADHD 症状，但不能减轻 RBD 症状。我们推测，该病例的 RBD 和 ADHD 症状与脑桥背外侧被盖核的功能障碍有关。极早发性 RBD 较为罕见，其特征尚不清楚。该病例中，背外侧被盖核功能障碍导致的 ADHD 可能构成一种 ADHD 亚型，该亚型常与极早发性 RBD 共病。
