Huang Emily, Sarin Ankit
Department of Surgery, University of California San Francisco, San Francisco, California.
Department of Surgery, Section of Colorectal Surgery, University of California San Francisco, San Francisco, California.
Clin Colon Rectal Surg. 2016 Dec;29(4):306-314. doi: 10.1055/s-0036-1584090.
Colonic polyps are considered to be precursors of colon cancer based on several different molecular pathway models and should be resected with a principle of complete excisional biopsy. Several techniques are available for excisional biopsy, ranging from endoscopic techniques such as snare polypectomy, endoscopic mucosal resection (EMR), and endoscopic submucosal dissection (ESD) to surgical colonic resection and colonic endolaparoscopic surgery (CELS). This article focuses on these modalities with contemporary recommendations for choice of modality based on the size and features of the polyp encountered upon endoscopy. In addition, the morphologically apparent risk factors for polyps harboring invasive malignancy are discussed along with implications for management. Current literature on the comparative risks and benefits of EMR, ESD, CELS, and surgical resection is reviewed, as well as recommendations regarding cancer risk and subsequent surveillance.
基于多种不同的分子通路模型,结肠息肉被认为是结肠癌的前体,应按照完整切除活检的原则进行切除。有多种技术可用于切除活检,从内镜技术如圈套息肉切除术、内镜黏膜切除术(EMR)和内镜黏膜下剥离术(ESD)到外科结肠切除术和结肠内镜腹腔镜手术(CELS)。本文重点介绍这些方式,并根据内镜检查时遇到的息肉大小和特征给出当代的方式选择建议。此外,还讨论了息肉伴有浸润性恶性肿瘤的形态学明显危险因素及其对治疗的影响。综述了关于EMR、ESD、CELS和手术切除的比较风险和益处的当前文献,以及关于癌症风险和后续监测的建议。