Szor Daniel José, Dias André Roncon, Pereira Marina Alessandra, Ramos Marcus Fernando Kodama Pertille, Zilberstein Bruno, Cecconello Ivan, Ribeiro Júnior Ulysses
Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2019 Nov 25;18:eAO4860. doi: 10.31744/einstein_journal/2020AO4860. eCollection 2020.
To evaluate the impact of neutrophil-lymphocyte ratio change after curative surgery for gastric cancer.
A retrospective analysis of patients with gastric cancer who underwent curative surgery between 2009 and 2017 was performed. A cutoff value was established for the neutrophil-lymphocyte ratio in the pre- and postoperative periods, according to the median value, and four subgroups were formed (low-low/low-high/high-low/high-high). Clinical-pathological and survival data were analyzed and related to these subgroups.
A total of 325 patients were included in the study. The cutoff values of the neutrophil-lymphocyte ratio were 2.14 and 1.8 for the pre and postoperative periods, respectively. In patients with stages I and II, the high-high subgroup presented worse overall survival (p=0.016) and disease-free survival (p=0.001). Complications were higher in the low-high subgroup of patients.
The neutrophil-lymphocyte ratio is a low cost, efficient and reproducible marker. The prognosis individualization can be performed according to the identification of subgroups at a higher risk of complications and worse prognosis.
评估胃癌根治性手术后中性粒细胞与淋巴细胞比值变化的影响。
对2009年至2017年间接受根治性手术的胃癌患者进行回顾性分析。根据中位数确定术前和术后中性粒细胞与淋巴细胞比值的临界值，并形成四个亚组（低-低/低-高/高-低/高-高）。分析临床病理和生存数据，并与这些亚组相关联。
共纳入325例患者进行研究。术前和术后中性粒细胞与淋巴细胞比值的临界值分别为2.14和1.8。在I期和II期患者中，高-高亚组的总生存期（p = 0.016）和无病生存期（p = 0.001）较差。低-高亚组患者的并发症发生率较高。
中性粒细胞与淋巴细胞比值是一种低成本、高效且可重复的标志物。可根据识别出的并发症风险较高和预后较差的亚组进行预后个体化。
