Gouveia M A
Department of Pathology, Faculty of Medicine, University of São Paulo.
Andrologia. 1988 May-Jun;20(3):225-31. doi: 10.1111/j.1439-0272.1988.tb01061.x.
Cadmium toxicity was tested on young male Wistar rats by injecting 1 mg/ml of cadmium chloride (CdCl2) intra-peritoneally. Post-mortem examination was done 4 hours, 24 hours and 14 days after cadmium administration to observe time-sequence cadmium-induced alterations in vascular permeability of the mesothelium in the pleura, peritoneum and tunica vaginals. This paper mainly reports the alterations observed in the testes. Vascular permeability was assessed by the colloidal carbon technique. Vascular labelling was evidenced as early as 4 hours after CdCl2, injection; 24 hours later severe oedema with leakage of particles to the interstitium and also into the tubules was patent. Fourteen days after CdCl2 administration atrophy of the testes with necrosis of the tubules, fibrosis of the interstitium and vascular thrombosis was found, compatible with chemical castration.
通过腹腔注射1毫克/毫升氯化镉（CdCl2）对年轻雄性Wistar大鼠进行镉毒性测试。在给予镉后4小时、24小时和14天进行尸检，以观察镉诱导的胸膜、腹膜和阴道膜间皮血管通透性随时间的变化。本文主要报告在睾丸中观察到的变化。通过胶体碳技术评估血管通透性。早在注射CdCl2后4小时就有血管标记出现；24小时后，出现严重水肿，颗粒渗漏到间质以及小管中。给予CdCl2 14天后，发现睾丸萎缩，伴有小管坏死、间质纤维化和血管血栓形成，符合化学去势。
