Saygi S, Deniz G, Kutsal O, Vural N
Department of Pharmacology and Toxicology, Gulhane Military Medical Academy and School, Etlik, Ankara, Turkey.
Biol Trace Elem Res. 1991 Dec;31(3):209-14. doi: 10.1007/BF02990191.
Male Wistar rats (n:20), at 5 wk of age, were given cadmium in drinking water (10 mg/L water) for 52 wk; 8 males and 20 female rats, as controls, were given tap water. At the end of 28 and 40 wk, some of the cadmium-treated males and control group male rats were sacrificed for the histopathological examination of testis, kidney, and liver. At the end of 56 wk, histopathological examinations were performed in the same way. Liver, kidney, and testis cadmium levels were also determined by atomic absorption spectrophotometry. All the cadmium-treated male rats showed pathological testicular alterations, and liver and kidney damage after chronic exposure. Cadmium levels were found to be highest in the kidney (1.009 +/- 0.034 microgram/g wet tissue in the infertile group). At the end of the 52-wk period, reproductive capacity of the cadmium-treated rats was investigated and was found to be lost in 39.89% of the animals.
5周龄的雄性Wistar大鼠（n = 20），饮用含镉（10毫克/升水）的水52周；作为对照，8只雄性大鼠和20只雌性大鼠饮用自来水。在28周和40周结束时，处死一些经镉处理的雄性大鼠和对照组雄性大鼠，对睾丸、肾脏和肝脏进行组织病理学检查。在56周结束时，以同样的方式进行组织病理学检查。还通过原子吸收分光光度法测定肝脏、肾脏和睾丸中的镉水平。所有经镉处理的雄性大鼠在慢性暴露后均出现睾丸病理改变以及肝脏和肾脏损伤。发现肾脏中的镉水平最高（不育组中为1.009±0.034微克/克湿组织）。在52周实验期结束时，对经镉处理的大鼠的生殖能力进行了研究，发现39.89%的动物丧失了生殖能力。
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