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非酒精性脂肪性肝病(NAFLD)中的饮食模式和成分:医疗保健提供者可以提供哪些关键信息?

Dietary Patterns and Components in Nonalcoholic Fatty Liver Disease (NAFLD): What Key Messages Can Health Care Providers Offer?

机构信息

Department of Medicine, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Community Health Sciences, O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.

出版信息

Nutrients. 2019 Nov 26;11(12):2878. doi: 10.3390/nu11122878.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a rising epidemic worldwide and will be the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplant within the next decade. NAFLD is considered as the hepatic manifestation of metabolic syndrome. Behaviors, such as a sedentary lifestyle and consuming a Western diet, have led to substantial challenges in managing NAFLD patients. With no curative pharmaceutical therapies, lifestyle modifications, including dietary changes and exercise, that ultimately lead to weight loss remain the only effective therapy for NAFLD. Multiple diets, including low-carbohydrate, low-fat, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean (MD) diets, have been evaluated. NAFLD patients have shown better outcomes with a modified diet, such as the MD diet, where patients are encouraged to increase the consumption of fruits and vegetables, whole grains, and olive oil. It is increasingly clear that a personalized approach to managing NAFLD patients, based on their preferences and needs, should be implemented. In our review, we cover NAFLD management, with a specific focus on dietary patterns and their components. We emphasize the successful approaches highlighted in recent studies to provide recommendations that health care providers could apply in managing their NAFLD patients.

摘要

非酒精性脂肪性肝病(NAFLD)是全球范围内日益流行的疾病,预计在未来十年内将成为肝硬化、肝细胞癌和肝移植的主要原因。NAFLD 被认为是代谢综合征的肝脏表现。久坐不动的生活方式和西式饮食等行为给 NAFLD 患者的管理带来了巨大挑战。由于没有有效的药物治疗方法,生活方式的改变,包括饮食的改变和运动,最终导致体重减轻,仍然是治疗 NAFLD 的唯一有效方法。已经评估了多种饮食方法,包括低碳水化合物、低脂肪、停止高血压的饮食方法(DASH)和地中海饮食(MD)。NAFLD 患者通过改良饮食(如 MD 饮食)可获得更好的结果,MD 饮食鼓励患者增加水果、蔬菜、全谷物和橄榄油的摄入。越来越明显的是,应该根据患者的喜好和需求,对 NAFLD 患者实施个性化的管理方法。在我们的综述中,我们涵盖了 NAFLD 的管理,特别关注饮食模式及其组成部分。我们强调了最近研究中突出的成功方法,为医疗保健提供者在管理其 NAFLD 患者时提供建议。

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