水果和蔬菜摄入量与非酒精性脂肪性肝病风险：一项观察性研究的荟萃分析

Fruit and vegetable intake and the risk of non-alcoholic fatty liver disease: a meta-analysis of observational studies.

作者信息

Wang Rui, Yan Ruijuan, Jiao Junzhe, Li Feilong, Zhang Haibo, Chang Zhanjie, Wei Hailiang, Yan Shuguang, Li Jingtao

机构信息

The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, China.

Department of Hepatology, The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.

出版信息

Front Nutr. 2024 Jun 21;11:1398184. doi: 10.3389/fnut.2024.1398184. eCollection 2024.

PURPOSE

This systematic review and meta-analysis of clinical observational studies aims to clarify the correlation between the intake levels of fruits and vegetables and non-alcoholic fatty liver disease (NAFLD).

MATERIALS AND METHODS

PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies on the association between vegetable or fruit intake with the risk of NAFLD from the foundation of each database up until September 2023. The relative risk (OR) and the 95% confidence interval (CI) were pooled for both the highest and lowest consumption levels of vegetables and fruits to explore their association with the incidence of NAFLD.

RESULTS

The meta-analysis encompassed 11 studies with a total of 493,682 patients. A higher consumption of vegetables (OR = 0.78, 95% CI = 0.67-0.91) and fruits (OR = 0.88, 95% CI = 0.83-0.93) was found to have a negative correlation with the risk of NAFLD, denoting an inverse association. This correlation, however, varied among different ethnic groups and gender.

CONCLUSIONS

Our results indicate that increased consumption of vegetables and fruits is associated with a reduced likelihood of developing NAFLD.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/PROSPERO/#searchadvanced, identifier: CRD42023460430.

目的

本对临床观察性研究的系统评价和荟萃分析旨在阐明水果和蔬菜摄入量与非酒精性脂肪性肝病（NAFLD）之间的相关性。

材料与方法

检索了PubMed、Embase、Web of Science和Cochrane图书馆，以查找从每个数据库建立至2023年9月关于蔬菜或水果摄入量与NAFLD风险之间关联的研究。汇总了蔬菜和水果最高和最低消费水平的相对风险（OR）及95%置信区间（CI），以探讨它们与NAFLD发病率的关联。

结果

荟萃分析纳入了11项研究，共493,682例患者。发现较高的蔬菜摄入量（OR = 0.78，95% CI = 0.67 - 0.91）和水果摄入量（OR = 0.88，95% CI = 0.83 - 0.93）与NAFLD风险呈负相关，表明存在反向关联。然而，这种相关性在不同种族和性别之间有所不同。