Keykhah M M, Smith D S, O'Neil J J, Harp J R
Department of Anesthesiology, Hahnemann, Philadelphia, PA 19102.
Anesthesiology. 1988 Oct;69(4):566-70. doi: 10.1097/00000542-198810000-00017.
The effects of intravenous administration of high-dose fentanyl (100 micrograms.kg-1, loading dose followed by an infusion of 200 micrograms.kg-1.h-1) were compared with those of a barbiturate (pentobarbital sodium 25 mg.kg-1, intraperitoneal) or hypothermia (rectal temperature 32 degrees C) on changes in cerebral cortical tissue levels of adenosine triphosphate (ATP), phosphocreatine (PCr), lactate, and glucose in severely hypoxemic rats (PaO2 13-23 mmHg for 20 min) with unilateral (left side) carotid ligation (10-12 animals in each group). Ligation of the carotid artery alone produced no change in brain high-energy metabolites, lactate, or glucose. The control values on the ligated side (nitrous oxide, 70%, + normoxia group) for cortical ATP, PCr, lactate, and glucose were 2.86 +/- 0.09 (mumol.g-1 wet weight, mean +/- 1 SE), 3.83 +/- 0.11, 1.68 +/- 0.21, and 3.29 +/- 0.47, respectively. Hypoxia (nitrous oxide, 70%, + hypoxia group) produced a significant (P less than 0.05) decrease in ATP (1.83 +/- 0.37) and PCr (1.93 +/- 0.48) and an increase in lactate (15.8 +/- 1.77) compared with the normoxic group, whereas brain glucose was not significantly changed (1.97 +/- 0.65). Fentanyl (fentanyl + hypoxia group) did not prevent the deleterious effects of hypoxia on cortical high energy metabolites (ATP, 2.0 +/- 0.27; PCr, 2.24 +/- 0.3) or lactate (19.33 +/- 3.16); however, fentanyl caused no alteration in high-energy cerebral metabolite concentrations in normoxic rats, nor did fentanyl produce a significant difference in brain tissue glucose or lactate.(ABSTRACT TRUNCATED AT 250 WORDS)
将大剂量芬太尼静脉注射（100微克·千克⁻¹，负荷剂量后以200微克·千克⁻¹·小时⁻¹的速度输注）的效果，与巴比妥酸盐（腹腔注射戊巴比妥钠25毫克·千克⁻¹）或低温（直肠温度32摄氏度）对严重低氧血症大鼠（动脉血氧分压13 - 23毫米汞柱，持续20分钟）单侧（左侧）颈动脉结扎（每组10 - 12只动物）后脑皮质组织中三磷酸腺苷（ATP）、磷酸肌酸（PCr）、乳酸和葡萄糖水平变化的影响进行了比较。单独结扎颈动脉对脑内高能代谢物、乳酸或葡萄糖没有影响。结扎侧（氧化亚氮70% + 常氧组）皮质ATP、PCr、乳酸和葡萄糖的对照值分别为2.86 ± 0.09（微摩尔·克⁻¹湿重，平均值 ± 1标准误）、3.83 ± 0.11、1.68 ± 0.21和3.29 ± 0.47。与常氧组相比，低氧（氧化亚氮70% + 低氧组）使ATP（1.83 ± 0.37）和PCr（1.93 ± 0.48）显著降低（P < 0.05），乳酸增加（15.8 ± 1.77），而脑葡萄糖无显著变化（1.97 ± 0.65）。芬太尼（芬太尼 + 低氧组）未能预防低氧对皮质高能代谢物（ATP，2.0 ± 0.27；PCr，2.24 ± 0.3）或乳酸（19.33 ± 3.16）的有害影响；然而，芬太尼对常氧大鼠脑内高能代谢物浓度无改变，对脑组织葡萄糖或乳酸也未产生显著差异。（摘要截断于250字）
