Kobayashi S, Yamaguchi S, Okada K, Kitani M, Yamashita K, Shimote K, Tsunematsu T
Third Division of Internal Medicine, Shimane Medical University, Japan.
Angiology. 1988 Nov;39(11):934-41. doi: 10.1177/000331978803901102.
The influence of long-term oral administration of buflomedil on regional cerebral blood flow was investigated in 10 patients with chronic cerebral infarction and mild to moderate mental deterioration. Patients were given 150 mg buflomedil three times daily for a period of eight weeks. Regional cerebral blood flow (rCBF) was measured in patients before they began buflomedil treatment and during the last week of treatment. The interval of the rCBF measurements in the control subjects (n = 12) ranged from seven to forty-eight days. Mental function in the patients studied was evaluated by use of Hasegawa's simple intelligence scale for the aged and Zung's self-rating depression scale, before and during the last week of buflomedil treatment. The results showed a mean increase in rCBF of 10.5% +/- 12.1% in the patient group. The control group demonstrated virtually no change in rCBF measurements. Improvements in the mental function scores of the buflomedil-treated group were noted, and 5 of the 10 patients reported improvement in subjective symptoms.
在10例患有慢性脑梗死且有轻度至中度智力衰退的患者中，研究了长期口服丁咯地尔对局部脑血流量的影响。患者每日3次服用150毫克丁咯地尔，为期8周。在患者开始丁咯地尔治疗前及治疗的最后一周测量局部脑血流量（rCBF）。对照受试者（n = 12）的rCBF测量间隔为7至48天。在丁咯地尔治疗前及治疗的最后一周，使用长谷川老年简易智力量表和zung自评抑郁量表对所研究患者的心理功能进行评估。结果显示，患者组的rCBF平均增加了10.5% +/- 12.1%。对照组的rCBF测量值几乎没有变化。观察到丁咯地尔治疗组的心理功能评分有所改善，10例患者中有5例报告主观症状有所改善。
