Cucinotta D, Aveni Casucci M A, Pedrazzi F, Ponari O, Capodaglio M, Valdina P, Toxiri I, Bartorelli L, Granata Q, Franzini C
Department of Geriatrics, Forlì Hospital, Italy.
J Int Med Res. 1992 Apr;20(2):136-49. doi: 10.1177/030006059202000206.
A study was carried out in 73 male or female patients suffering from mild vascular dementia. The experimental protocol involved an initial run-in period (14 days) and subsequent double-blind, randomized treatment with 300 mg buflomedil or placebo given orally twice daily for 90 days. At the end of this treatment period, all patients received buflomedil for a further 90 days and, thereafter, patients received buflomedil or no further treatment for another 90 days. The efficacy of buflomedil was monitored using rating scales and neuropsychological tests. The findings of the study indicate that buflomedil improved the symptoms of vascular dementia; the most improvement was recorded in patients who had received buflomedil for the longest period. Inadequacy, cooperation, psycho-affective disorders, self-care and somatic complaints were positively influenced by buflomedil. The efficacy of buflomedil may be due to its effects on platelet aggregation and improvement in blood flow distribution to the ischaemic brain and oxygenation of brain tissue.
对73例患有轻度血管性痴呆的男性或女性患者进行了一项研究。实验方案包括一个初始导入期（14天），随后进行双盲、随机治疗，口服300毫克丁咯地尔或安慰剂，每日两次，持续90天。在该治疗期结束时，所有患者再接受90天的丁咯地尔治疗，此后，患者再接受90天的丁咯地尔治疗或不再接受进一步治疗。使用评定量表和神经心理学测试监测丁咯地尔的疗效。该研究结果表明，丁咯地尔改善了血管性痴呆的症状；在接受丁咯地尔治疗时间最长的患者中记录到的改善最为明显。丁咯地尔对不足、合作、心理情感障碍、自我护理和躯体不适有积极影响。丁咯地尔的疗效可能归因于其对血小板聚集的作用以及对缺血性脑血流分布和脑组织氧合的改善。
