Yaseen Muhammad Talha, Aziz Pir Abdul Ahad, Siddique Kashif, Tariq Taimoor Ali
Department of Radiology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.
J Coll Physicians Surg Pak. 2019 Dec;29(12):S86-S88. doi: 10.29271/jcpsp.2019.12.S86.
Neurolymphomatosis (NL) is an uncommon clinical condition, characterised by lymphomatous infiltration of the central and/or peripheral nervous system. Most often it is caused by B-cell non-Hodgkin's lymphoma (NHL). Clinically, patients usually present with neuropathy involving the nerve roots, plexuses, peripheral or cranial nerves. NL usually occurs as a complication of prior lymphoma, but it can also present in the form of relapsed lymphoma. It is important to diagnose and start early treatment in all cases of nodal or visceral (including neural) lymphoma with chemo and/or radiation therapy. The PET-CT and MRI can help in making diagnosis. We are presenting a case of 28-year male patient, diagnosed as diffuse large B-cell lymphoma on the background of follicular lymphoma, which initially responded to treatment but then presented with NL, based on clinical history and radiological findings which were confirmed by histopathology.
神经淋巴瘤（NL）是一种罕见的临床病症，其特征是中枢和/或周围神经系统出现淋巴瘤浸润。最常见的病因是B细胞非霍奇金淋巴瘤（NHL）。临床上，患者通常表现为累及神经根、神经丛、周围神经或颅神经的神经病变。NL通常是先前淋巴瘤的并发症，但也可表现为复发性淋巴瘤。对于所有结节性或内脏性（包括神经）淋巴瘤病例，通过化疗和/或放疗进行诊断并尽早开始治疗非常重要。PET-CT和MRI有助于做出诊断。我们报告一例28岁男性患者，在滤泡性淋巴瘤背景下被诊断为弥漫性大B细胞淋巴瘤，最初对治疗有反应，但随后出现了神经淋巴瘤，这是根据临床病史和影像学检查结果得出的诊断，并经组织病理学证实。
