Potter J L, Krill C E, Neal D, Kofron W G
Department of Pathology, Children's Hospital Medical Center, Akron, Ohio 44308.
Ann Emerg Med. 1988 Oct;17(10):1098-100. doi: 10.1016/s0196-0644(88)80455-4.
An acute cyanotic episode due to methemoglobinemia occurred in a 16-month old girl following the ingestion of N,N-dimethyl-p-toluidine, a commercially available component used in the production of artificial fingernails. The amount of the parent compound ingested was about 6 mg/kg of body weight. Administration of methylene blue was effective in the reversal of the methemoglobinemia. In vitro studies suggest that the activity of the compound was probably due to its biochemical transformation to the toxic metabolite p-methylphenylhydroxylamine. We expand the list of aromatic amino or nitro compounds and their derivatives capable of producing methemoglobinemia and call attention to the hazard of their ingestion.
一名16个月大的女孩在摄入N,N-二甲基对甲苯胺（一种用于生产人造指甲的市售成分）后，因高铁血红蛋白血症发生急性发绀发作。摄入的母体化合物量约为6毫克/千克体重。亚甲蓝治疗有效地逆转了高铁血红蛋白血症。体外研究表明，该化合物的活性可能是由于其生化转化为有毒代谢物对甲基苯羟胺。我们扩充了能够导致高铁血红蛋白血症的芳香族氨基或硝基化合物及其衍生物的清单，并提请注意摄入它们的危害。
