Fundación Respira, Programa Integrado de Investigación en Tuberculosis (PII-TB), Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Barcelona, España; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, España; Fundación Unidad de Investigación en Tuberculosis (fuiTB), Barcelona, España.
Servicio de Neumología, Hospital Universitario San Agustín, Avilés, Asturias, España; Fundación Respira, Programa Integrado de Investigación en Tuberculosis (PII-TB), Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Barcelona, España.
Arch Bronconeumol (Engl Ed). 2020 Aug;56(8):483-492. doi: 10.1016/j.arbres.2019.10.006. Epub 2019 Nov 25.
The objective of the study was to determine the trend of variables related to tuberculosis (TB) from the Integrated Tuberculosis Research Program (PII-TB) registry of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR), and to evaluate the PII-TB according to indicators related to its scientific objectives.
Cross-sectional, population-based, multicenter study of new TB cases prospectively registered in the PII-TB between 2006 and 2016. The time trend of quantitative variables was calculated using a lineal regression model, and qualitative variables using the χy test for lineal trend.
A total of 6,892 cases with an annual median of 531 were analyzed. Overall, a significant downward trend was observed in women, immigrants, prisoners, and patients initially treated with 3 drugs. Significant upward trends were observed in patients aged 40-50 and > 50 years, first visit conducted by a specialist, hospitalization, diagnostic delay, disseminated disease and single extrapulmonary location, culture(+), sensitivity testing performed, drug resistance, directly observed treatment, prolonged treatment, and death from another cause. The scientific objectives of the PII-TB that showed a significant upward trend were publications, which reached a maximum of 8 in 2016 with a total impact factor of 49,664, numbers of projects initiated annually, presentations at conferences, and theses.
PII-TB provides relevant information on TB and its associated factors in Spain. A large team of researchers has been created; some scientific aspects of the registry were positive, while others could have been improved.
本研究旨在确定西班牙肺病学和胸外科学会（SEPAR）的综合结核病研究计划（PII-TB）登记处中与结核病（TB）相关的变量趋势，并根据与科学目标相关的指标评估 PII-TB。
这是一项在 2006 年至 2016 年期间前瞻性登记在 PII-TB 中的新结核病病例的横断面、基于人群的、多中心研究。使用线性回归模型计算定量变量的时间趋势，使用线性趋势 χy 检验计算定性变量的时间趋势。
共分析了 6892 例患者，每年中位数为 531 例。总体而言，女性、移民、囚犯以及最初接受 3 种药物治疗的患者数量呈显著下降趋势。40-50 岁和 >50 岁患者、专科首诊、住院、诊断延迟、播散性疾病和单发性肺外部位、培养（+）、进行药敏试验、耐药性、直接观察治疗、延长治疗以及因其他原因死亡的患者数量呈显著上升趋势。PII-TB 中显示出显著上升趋势的科学目标是出版物，2016 年达到了 8 篇的峰值，总影响因子为 49664，每年启动的项目数量、会议演讲和论文数量也有所增加。
PII-TB 提供了西班牙结核病及其相关因素的相关信息。已经创建了一个庞大的研究团队；该登记处的一些科学方面是积极的，而其他方面则可以改进。
