男性慢性恰特草、大麻和海洛因滥用者的性腺和皮质醇激素水平

Gonadal and Cortisol Hormone Profile among Male Chronic Khat, Marijuana, and Heroin Abuses.

作者信息

Yibrah Meseret, Negesso Abebe Edao, Gebregziabher Atsbeha, Challa Feyissa, Mudi Kissi, Tesfay Feven, Gebretsadkan Mehari, Kinde Samuel, Asmelash Daniel

机构信息

Department of Medical Laboratory Science, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Department of Medical Laboratory Science, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

Int J Endocrinol. 2019 Nov 3;2019:4178241. doi: 10.1155/2019/4178241. eCollection 2019.

DOI:10.1155/2019/4178241

PMID:31781207

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6874973/

Abstract

BACKGROUND

Drugs of abuse could interfere with the hypothalamic-pituitary-gonadal axis, causing impaired functions of the gland and associated functions of target organs. Drugs of abuse tend to cause changes in the endocrine system, and these changes could be physiological, molecular, biochemical, genetic, and cellular.

METHOD

A case-control study design was conducted from a total of 171 male consented study participants (148 drug abusers and 23 controls). The serum gonadal and cortisol hormone levels were assayed using the electrochemiluminescence immunoassay method. Socio-demographic variables were collected using a semi-structured questionnaire by the interview method. Nonparametric statistical tools (Mann-Whitney test and median) were used to compare the groups. In all cases, < 0.05 was considered statistically significant.

RESULT

The median age for drug abusers and control groups was 27, and the age difference between drug abusers and control group was not statistically important. The median estradiol levels among chronic khat chewers (39.4 pg/ml), marijuana (44 pg/mL), and users of heroin (40.2 pg/mL) were significantly higher than control groups (23 pg/mL), < 0.003. However, the median luteinizing hormone levels among chronic khat chewers (5 IU/L), marijuana users (5 IU/L), and heroin users (5.6 IU/L) were significantly lower than those of control groups (6.2 IU/L), < 0.02. The median testosterone levels among chronic khat chewers (6.1 ng/mL), marijuana users (6.3 ng/mL), and heroin users (6.6 ng/mL) were significantly lower than control groups (8.0 ng/mL), < 0.003. However, cortisol and follicle stimulating hormone did not show statistically significant difference between users of khat, marijuana, and heroin compared with the control group.

CONCLUSION

The drug abuser group had significantly lower testosterone and luteinizing hormone levels compared with control groups. Drug abuse has been shown to affect gonadal hormones in an unusual physiological phenomenon. These findings reveal the need for intervention programs to solve these problems.

摘要

背景

滥用药物可能会干扰下丘脑 - 垂体 - 性腺轴，导致腺体功能以及靶器官相关功能受损。滥用药物往往会引起内分泌系统的变化，这些变化可能是生理、分子、生化、遗传和细胞层面的。

方法

采用病例对照研究设计，共有171名男性同意参与研究（148名药物滥用者和23名对照组）。使用电化学发光免疫分析法测定血清性腺激素和皮质醇激素水平。通过访谈法使用半结构化问卷收集社会人口统计学变量。使用非参数统计工具（曼 - 惠特尼检验和中位数）比较各组。在所有情况下，P<0.05被认为具有统计学意义。

结果

药物滥用者组和对照组的年龄中位数均为27岁，药物滥用者组与对照组之间的年龄差异无统计学意义。慢性巧茶咀嚼者（39.4 pg/ml）、大麻使用者（44 pg/mL）和海洛因使用者（40.2 pg/mL）的雌二醇水平中位数显著高于对照组（23 pg/mL），P<0.003。然而，慢性巧茶咀嚼者（5 IU/L）、大麻使用者（5 IU/L）和海洛因使用者（5.6 IU/L）的促黄体生成素水平中位数显著低于对照组（6.2 IU/L），P<0.02。慢性巧茶咀嚼者（6.1 ng/mL）、大麻使用者（6.3 ng/mL）和海洛因使用者（6.6 ng/mL）的睾酮水平中位数显著低于对照组（8.0 ng/mL），P<0.003。然而，与对照组相比，巧茶、大麻和海洛因使用者的皮质醇和促卵泡激素未显示出统计学显著差异。