藤黄双异戊烯基呫吨酮D通过抑制自噬调节口腔鳞状细胞癌细胞系中的上皮-间质转化
Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines.
作者信息
Yu Su-Bin, Kang Hae-Mi, Park Dan-Bi, Park Bong-Soo, Kim In-Ryoung
机构信息
Department of Oral Anatomy, School of Dentistry, Pusan National University, 49 Busandaehak-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea.
BK21 PLUS Project, School of Dentistry, Pusan National University, 49 Busandaehak-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea.
出版信息
Evid Based Complement Alternat Med. 2019 Oct 31;2019:5213028. doi: 10.1155/2019/5213028. eCollection 2019.
Cudraxanthone D (CD), derived from the root bark of , is a natural xanthone compound. However, the biological activity of CD in terms of human metabolism has been barely reported to date. Autophagy is known as a self-degradation process related to cancer cell viability and metastasis. Herein, we investigated the effects of CD on human oral squamous cell carcinoma (OSCC) metastatic related cell phenotype. We confirmed that CD effectively decreased proliferation and viability in a time- and dose-dependent manner in human OSCC cells. In addition, OSCC cell migration, invasion, and EMT were inhibited by CD. To further determine the underlying mechanism of CD's inhibition of cell metastatic potential, we established the relationship between EMT and autophagy in OSCC cells. Thus, our findings indicated that CD inhibited the potential metastatic abilities of OSCC cells by attenuating autophagy.
藤黄双黄酮D（CD）源自[植物名称]的根皮，是一种天然的氧杂蒽酮化合物。然而，迄今为止，关于CD在人体新陈代谢方面的生物活性鲜有报道。自噬是一种与癌细胞活力和转移相关的自我降解过程。在此，我们研究了CD对人口腔鳞状细胞癌（OSCC）转移相关细胞表型的影响。我们证实，CD能以时间和剂量依赖性方式有效降低人OSCC细胞的增殖和活力。此外，CD抑制了OSCC细胞的迁移、侵袭和上皮-间质转化（EMT）。为了进一步确定CD抑制细胞转移潜能的潜在机制，我们建立了OSCC细胞中EMT与自噬之间的关系。因此，我们的研究结果表明，CD通过减弱自噬来抑制OSCC细胞的潜在转移能力。
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