Töyry S, Fräki J, Tammi R
Department of Anatomy, University of Kuopio, Finland.
Arch Dermatol Res. 1988;280(5):282-5. doi: 10.1007/BF00440601.
Numbers and volume fractions of mast cells in nonlesional and chronic lesional skin of psoriatic patients were compared with those of normal control skin. Mast cell densities were similar in psoriatic nonlesional and normal control skin. The superficial dermis of lesional psoriatic skin contained more mast cells than either normal or nonlesional psoriatic skin. Neither PUVA nor corticosteroid treatment for 3-4 weeks significantly reduced mast cell numbers or volume fractions in lesional skin, although both treatments clinically and histologically markedly improved the lesions. The results indicate that the initiation of the healing process in psoriatic plaques is not correlated with the mast cell density. The remaining high mast cell density may be normalized later, or after a longer therapy.
将银屑病患者非皮损区和慢性皮损区皮肤中的肥大细胞数量和体积分数与正常对照皮肤进行比较。银屑病非皮损区皮肤和正常对照皮肤中的肥大细胞密度相似。银屑病皮损区皮肤的浅表真皮层所含肥大细胞比正常皮肤或银屑病非皮损区皮肤都多。尽管补骨脂素紫外线A（PUVA）和皮质类固醇治疗3 - 4周在临床和组织学上均显著改善了皮损，但均未显著降低皮损区皮肤中的肥大细胞数量或体积分数。结果表明，银屑病斑块愈合过程的启动与肥大细胞密度无关。剩余的高肥大细胞密度可能在后期或经过更长时间的治疗后恢复正常。
