Cardanho-Ramos Carlos, Faria-Pereira Andreia, Morais Vanessa Alexandra
Instituto de Medicina Molecular - João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Cytoskeleton (Hoboken). 2020 Mar;77(3-4):65-75. doi: 10.1002/cm.21585. Epub 2019 Dec 9.
Mitochondria are crucial to support synaptic activity, particularly through ATP production and Ca homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub-compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post-mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton proteins have been implicated in mitophagy. Therefore, all of these processes are orchestrated by the crosstalk between mitochondria and the neuronal cytoskeleton to form a coordinated and tuned symphony.
线粒体对于支持突触活动至关重要，特别是通过产生ATP和维持钙稳态来实现。这意味着线粒体需要在整个不同的神经元亚区室中良好分布。为了实现这一点，需要对几种神经元细胞骨架成分进行严格而精确的调控，以便运输和停靠线粒体。作为有丝分裂后的细胞，神经元高度依赖线粒体质量控制机制，并且几种细胞骨架蛋白与线粒体自噬有关。因此，所有这些过程都是由线粒体和神经元细胞骨架之间的相互作用精心安排的，从而形成一曲协调且和谐的交响乐。
