De Giovanni Carla, Nicoletti Giordano, Landuzzi Lorena, Palladini Arianna, Lollini Pier-Luigi, Nanni Patrizia
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna I-40126, Italy.
Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna I-40136, Italy.
Cancers (Basel). 2019 Nov 27;11(12):1889. doi: 10.3390/cancers11121889.
The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.
TS/A细胞系于1983年从一只近交系BALB/c雌性小鼠自发产生的乳腺肿瘤中建立。其特性（异质性、低免疫原性和转移能力）使TS/A细胞系适合作为肿瘤-宿主相互作用研究和基因治疗方法的临床前模型。通过文献综述得出的TS/A综合生物学概况可能是描述乳腺癌精确实验模型的一条途径。
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