Fenton Matthew, Yoneyama Miki, Wennerberg Erik, Lund Tom, Tutt Andrew, Melcher Alan, Demaria Sandra, Somaiah Navita
Division of Radiotherapy and Imaging, Institute of Cancer Research, London, UK.
Royal Marsden NHS Foundation Trust, London, UK.
NPJ Breast Cancer. 2025 Jul 24;11(1):77. doi: 10.1038/s41523-025-00796-x.
Hormone receptor-positive breast cancers are a diverse group of tumours, with only some responding well to immunotherapy. Alternative combination strategies such as radiotherapy present an exciting opportunity to improve immunotherapy responses. We review an intriguing overlap between the impact of oestrogen signalling and radiation on multiple signalling pathways and immune cells that may be exploited for therapeutic gains in breast cancer. This is synthesised with the pre-clinical data and clinical trial landscape supporting the use of combined radiation and immunotherapy to derive insights for future neo-adjuvant trial design.
激素受体阳性乳腺癌是一组多样化的肿瘤，只有一部分对免疫疗法反应良好。放疗等替代联合策略为改善免疫疗法反应提供了令人兴奋的机会。我们综述了雌激素信号传导和辐射对多种信号通路及免疫细胞的影响之间有趣的重叠，这可能被用于乳腺癌治疗获益。结合临床前数据和支持联合放疗与免疫疗法应用的临床试验情况，以获得对未来新辅助试验设计的见解。
