精神分裂症患者中11C-氯丙嗪的脑部分布及动力学：正电子发射断层扫描研究
Brain distribution and kinetics of 11C-chlorpromazine in schizophrenics: positron emission tomography studies.
作者信息
Comar D, Zarifian E, Verhas M, Soussaline F, Maziere M, Berger G, Loo H, Cuche H, Kellershohn C, Deniker P
出版信息
Psychiatry Res. 1979 Jul;1(1):23-9. doi: 10.1016/0165-1781(79)90024-6.
The positron emitter 11C (20 minutes half-life) permits the labeling of chlorpromazine (CPZ) and the study of its distribution in humans by external counting. Trace amounts of 11C-CPZ were injected intravenously into 22 schizophrenic patients all untreated for several months with neuroleptics. The brain uptake was 6.04 +/- 1.6% of the injected dose 15 minutes after the injection, and it remained constant for 45 minutes. By positron emission tomography, the drug distribution was shown to be in the gray matter, and such structures as the cortex, caudate nucleus, thalamus and putamen could be identified. This new methodology will be helpful in studying specific receptors in humans in a noninvasive way.
正电子发射体11C（半衰期20分钟）可用于标记氯丙嗪（CPZ），并通过体外计数研究其在人体中的分布。向22例精神分裂症患者静脉注射微量的11C-CPZ，这些患者均已停用抗精神病药物数月。注射后15分钟，脑摄取量为注射剂量的6.04±1.6%，并在45分钟内保持恒定。通过正电子发射断层扫描显示，药物分布于灰质中，可识别出皮质、尾状核、丘脑和壳核等结构。这种新方法将有助于以非侵入性方式研究人体中的特定受体。
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