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撤回:过表达 microRNA-26a-5p 的人骨髓间充质干细胞来源的外泌体通过下调 PTGS2 缓解骨关节炎。

RETRACTED: Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2.

机构信息

Department of Orthopaedics, the First Hospital of China Medical University, Shenyang 110001, PR China.

Department of Orthopaedics, the First Hospital of China Medical University, Shenyang 110001, PR China.

出版信息

Int Immunopharmacol. 2020 Jan;78:105946. doi: 10.1016/j.intimp.2019.105946. Epub 2019 Nov 26.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figures 2E, 3D and F, 4B, E+G, 5D+I, and 6D+F, which appear to have a similar phenotype as contained in many other publications, detailed here: https://pubpeer.com/publications/73C0A79F5EDF9ECC9818CE2D9B2A09; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. The provenance of the flow cytometry data in Figure 5A was also questioned, as it appeared to have histograms that were hand drawn. The journal requested the corresponding author comment on these concerns and provide the raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

摘要

本文已被撤回

请参阅爱思唯尔撤稿政策(http://www.elsevier.com/locate/withdrawalpolicy)。应主编要求,撤回本文。对图 2E、3D 和 F、4B、E+G、5D+I 和 6D+F 中的 Western blot 结果的可靠性提出了质疑,这些结果似乎与许多其他出版物中包含的表型相似,详细信息如下:https://pubpeer.com/publications/73C0A79F5EDF9ECC9818CE2D9B2A09;和这里:https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249。图 5A 中的流式细胞术数据的来源也受到质疑,因为它似乎有手绘的直方图。期刊要求通讯作者对这些问题发表评论并提供原始数据。作者没有回复这一要求,因此主编决定撤回这篇文章。

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