• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

益生菌摄入可预防夜班护士中 HDAC11 诱导的 DEC205+树突状细胞功能障碍。

Probiotics ingestion prevents HDAC11-induced DEC205+ dendritic cell dysfunction in night shift nurses.

机构信息

Department of Nursing, First Hospital of Shanxi Medical University, Taiyuan, China.

Department of Respirology, Second Affiliated Hospital, Harbin Medical University, Harbin, China.

出版信息

Sci Rep. 2019 Nov 29;9(1):18002. doi: 10.1038/s41598-019-54558-4.

DOI:10.1038/s41598-019-54558-4
PMID:31784669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6884592/
Abstract

It is known that the day-night shift-rotation has a negative impact on the immune system. The underlying mechanism remains to be further investigated. Probiotics have regulatory effects on immune functions. This study aims to investigate the role of probiotic ingestion in preventing the DEC205 dendritic cell (decDC) dysfunction in day-night shift-engaging nurses. In this study, blood samples were collected from day-night shift-rotating nurses who took or did not take yogurt (containing C. Butyricum) during the night shift (NS). decDC functions were evaluated with pertinent immunological approaches. We observed that the immune tolerogenic functions and interleukin (IL)-10 expression were impaired in decDCs of nurses after NS. HDAC11 was detected in decDCs that was markedly up regulated after NS. The HDAC11 levels were negatively correlated with the immune tolerogenic functions in decDCs. Ingestion of probiotic-containing yogurt during NS efficiently suppressed Bmal1 and HDAC11 levels as well as up regulated the immune regulatory functions in decDCs. In conclusion, NS has a negative impact on decDC immune tolerogenic functions, which can be prevented by ingesting probiotics-containing yogurt during NS.

摘要

众所周知，昼夜倒班对免疫系统有负面影响。其潜在的机制仍有待进一步研究。益生菌对免疫功能具有调节作用。本研究旨在探讨摄入益生菌在预防昼夜倒班护士 DEC205 树突状细胞（decDC）功能障碍中的作用。在这项研究中，采集了昼夜倒班护士在夜班（NS）期间服用或未服用酸奶（含 C. Butyricum）的血样。通过相关免疫方法评估 decDC 功能。我们观察到，NS 后护士的 decDC 免疫耐受功能和白细胞介素（IL）-10 表达受损。在 NS 后，检测到 decDC 中 HDAC11 明显上调。HDAC11 水平与 decDC 中的免疫耐受功能呈负相关。在 NS 期间摄入含益生菌的酸奶可有效抑制 Bmal1 和 HDAC11 水平，并上调 decDC 的免疫调节功能。总之，NS 对 decDC 的免疫耐受功能有负面影响，而在 NS 期间摄入含益生菌的酸奶可以预防这种影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/5b4b81688313/41598_2019_54558_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/53ac8cd20b8c/41598_2019_54558_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/25c24515f770/41598_2019_54558_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/2724d560601c/41598_2019_54558_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/e45581a83140/41598_2019_54558_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/7c5919a89a34/41598_2019_54558_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/5b4b81688313/41598_2019_54558_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/53ac8cd20b8c/41598_2019_54558_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/25c24515f770/41598_2019_54558_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/2724d560601c/41598_2019_54558_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/e45581a83140/41598_2019_54558_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/7c5919a89a34/41598_2019_54558_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dc7/6884592/5b4b81688313/41598_2019_54558_Fig6_HTML.jpg

相似文献

1
Probiotics ingestion prevents HDAC11-induced DEC205+ dendritic cell dysfunction in night shift nurses.益生菌摄入可预防夜班护士中 HDAC11 诱导的 DEC205+树突状细胞功能障碍。
Sci Rep. 2019 Nov 29;9(1):18002. doi: 10.1038/s41598-019-54558-4.
2
Mal-deficiency impairs the tolerogenicity of dendritic cell of patients with allergic rhinitis.免疫缺陷损害变应性鼻炎患者树突状细胞的免疫耐受性。
Cell Immunol. 2019 Oct;344:103930. doi: 10.1016/j.cellimm.2019.103930. Epub 2019 Jun 6.
3
Circadian protein CLOCK modulates regulatory B cell functions of nurses engaging day-night shift rotation.生物钟蛋白 CLOCK 调节倒班护士的调节性 B 细胞功能。
Cell Signal. 2022 Aug;96:110362. doi: 10.1016/j.cellsig.2022.110362. Epub 2022 May 26.
4
Probiotics, Anticipation Stress, and the Acute Immune Response to Night Shift.益生菌、预期应激与夜间轮班的急性免疫反应。
Front Immunol. 2021 Jan 28;11:599547. doi: 10.3389/fimmu.2020.599547. eCollection 2020.
5
alleviates intestinal low-grade inflammation in TNBS-induced irritable bowel syndrome in mice by regulating functional status of lamina propria dendritic cells.通过调节固有层树突状细胞的功能状态，减轻三硝基苯磺酸诱导的小鼠肠易激综合征的肠道低度炎症。
World J Gastroenterol. 2019 Sep 28;25(36):5469-5482. doi: 10.3748/wjg.v25.i36.5469.
6
Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205.角蛋白通过树突状细胞受体DEC205/CD205介导对凋亡细胞和坏死细胞的识别。
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13438-13443. doi: 10.1073/pnas.1609331113. Epub 2016 Nov 7.
7
Bacterial probiotic modulation of dendritic cells.细菌益生菌对树突状细胞的调节作用。
Infect Immun. 2004 Jun;72(6):3299-309. doi: 10.1128/IAI.72.6.3299-3309.2004.
8
Murine Flt3 ligand expands distinct dendritic cells with both tolerogenic and immunogenic properties.小鼠Flt3配体可扩增具有致耐受性和免疫原性特性的不同树突状细胞。
J Immunol. 2003 Apr 1;170(7):3554-64. doi: 10.4049/jimmunol.170.7.3554.
9
Non-small Cell Lung Cancer Cells Modulate the Development of Human CD1c Conventional Dendritic Cell Subsets Mediated by CD103 and CD205.非小细胞肺癌细胞通过 CD103 和 CD205 调节人类 CD1c 常规树突状细胞亚群的发育。
Front Immunol. 2019 Dec 10;10:2829. doi: 10.3389/fimmu.2019.02829. eCollection 2019.
10
Circadian gene methylation in rotating-shift nurses: a cross-sectional study.轮班护士的昼夜节律基因甲基化：一项横断面研究。
Chronobiol Int. 2018 Jan;35(1):111-121. doi: 10.1080/07420528.2017.1388252. Epub 2017 Nov 16.

引用本文的文献

1
HDAC11, an emerging therapeutic target for metabolic disorders.HDAC11，代谢紊乱的新兴治疗靶点。
Front Endocrinol (Lausanne). 2022 Oct 20;13:989305. doi: 10.3389/fendo.2022.989305. eCollection 2022.
2
A randomized trial of probiotic supplementation in nurses to reduce stress and viral illness.益生菌补充剂对护士压力和病毒感染影响的随机试验
Sci Rep. 2022 Aug 30;12(1):14742. doi: 10.1038/s41598-022-19104-9.
3
VEGF-A controls the expression of its regulator of angiogenic functions, dopamine D2 receptor, on endothelial cells.

本文引用的文献

1
Infection of Dendritic Cells With subspecies Exhibits a Functionally Tolerogenic Phenotype in Response to Toll-Like Receptor Agonists IL-10/Cox2/PGE2/EP2 Axis.用该亚种感染树突状细胞，在对 Toll 样受体激动剂的应答中呈现出功能上的耐受性表型，涉及白细胞介素-10/环氧化酶 2/前列腺素 E2/前列腺素 E 受体 2 轴。
Front Microbiol. 2019 Aug 7;10:1795. doi: 10.3389/fmicb.2019.01795. eCollection 2019.
2
Time is on the Immune System's Side, Yes it is.时间站在免疫系统这一边，是的，它站在那边。
Yale J Biol Med. 2019 Jun 27;92(2):225-231. eCollection 2019 Jun.
3
Dysregulation of Circadian Rhythm Gene Expression in Cystic Fibrosis Mice.
VEGF-A 控制其血管生成功能调节剂多巴胺 D2 受体在血管内皮细胞上的表达。
J Cell Sci. 2022 Jun 1;135(11). doi: 10.1242/jcs.259617. Epub 2022 May 31.
4
Dopamine Prevents Ultraviolet B-induced Development and Progression of Premalignant Cutaneous Lesions through its D Receptors.多巴胺通过 D 受体预防紫外线 B 诱导的皮肤癌前病变的发展和进展。
Cancer Prev Res (Phila). 2021 Jul;14(7):687-696. doi: 10.1158/1940-6207.CAPR-21-0052. Epub 2021 Apr 12.
5
Chebulinic acid is a safe and effective antiangiogenic agent in collagen-induced arthritis in mice.齐墩果酸是一种安全有效的抗血管生成药物，可用于治疗胶原诱导性关节炎的小鼠模型。
Arthritis Res Ther. 2020 Nov 23;22(1):273. doi: 10.1186/s13075-020-02370-1.
囊性纤维化小鼠中昼夜节律基因表达的失调
J Circadian Rhythms. 2019 Apr 18;17:2. doi: 10.5334/jcr.175.
4
HDAC inhibitors in liver cancer: which route to take?肝癌中的组蛋白去乙酰化酶抑制剂：该走哪条路？
Expert Rev Gastroenterol Hepatol. 2019 Jun;13(6):515-517. doi: 10.1080/17474124.2019.1605289. Epub 2019 Apr 17.
5
Circadian Rhythms: Will It Revolutionise the Management of Diseases?昼夜节律：它会彻底改变疾病的管理方式吗？
J Lifestyle Med. 2019 Jan;9(1):1-11. doi: 10.15280/jlm.2019.9.1.1. Epub 2019 Jan 31.
6
Working against the biological clock: a review for the Occupational Physician.与生物钟作斗争：职业医生的综述。
Ind Health. 2019 Sep 26;57(5):557-569. doi: 10.2486/indhealth.2018-0173. Epub 2019 Feb 22.
7
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.短链脂肪酸戊酸盐通过调节淋巴细胞的代谢 - 表观遗传串扰来抑制自身免疫。
Nat Commun. 2019 Feb 15;10(1):760. doi: 10.1038/s41467-019-08711-2.
8
Beneficial Effects of Probiotic Consumption on the Immune System.益生菌摄入对免疫系统的有益影响。
Ann Nutr Metab. 2019;74(2):115-124. doi: 10.1159/000496426. Epub 2019 Jan 23.
9
Circadian protein CLK suppresses transforming growth factor-β expression in peripheral B cells of nurses with day-night shift rotation.昼夜节律蛋白CLK抑制昼夜轮班护士外周B细胞中转化生长因子-β的表达。
Am J Transl Res. 2018 Dec 15;10(12):4331-4337. eCollection 2018.
10
Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function.抑制素通过调节树突状细胞功能调节外周调节性 T 细胞的诱导。
FEBS Open Bio. 2018 Dec 11;9(1):137-147. doi: 10.1002/2211-5463.12555. eCollection 2019 Jan.