Cappuccio F P, Sagnella G A, Leathard H L, Markandu N D, MacGregor G A
Department of Medicine, Charing Cross & Westminster Medical School, London, United Kingdom.
Artery. 1988;15(6):346-52.
The effect of plasma from patients with essential hypertension and from normotensive subjects on the contractile response to noradrenaline and potassium chloride has been investigated using human isolated arteries. After incubation with plasma from normotensive subjects, there was no change in the contractile response to either noradrenaline (-3.0 +/- 5.4%; P = NS) or potassium chloride (3.2 +/- 3.0%; P = NS). After incubation with plasma from patients with essential hypertension, the contractile response to noradrenaline was significantly increased (24.8 +/- 9.8%; P less than 0.01) whereas that to potassium chloride did not change (-0.4 +/- 3.7%; P = NS). The change in the contractile response to noradrenaline in the presence of plasma from hypertensive patients was significantly higher than that obtained in the presence of plasma from normotensive subjects (P less than 0.03) whereas that to potassium chloride was not different between groups (P = NS). These findings suggest that the increased vascular reactivity of human arteries in the presence of hypertensive plasma could be related to specific mechanisms requiring receptor-mediated activation of the vascular smooth muscle cell.
利用人体离体动脉研究了原发性高血压患者和血压正常者的血浆对去甲肾上腺素和氯化钾收缩反应的影响。用血压正常者的血浆孵育后，对去甲肾上腺素（-3.0±5.4%；P=无显著性差异）或氯化钾（3.2±3.0%；P=无显著性差异）的收缩反应均无变化。用原发性高血压患者的血浆孵育后，对去甲肾上腺素的收缩反应显著增加（24.8±9.8%；P＜0.01），而对氯化钾的收缩反应未改变（-0.4±3.7%；P=无显著性差异）。在高血压患者血浆存在的情况下，对去甲肾上腺素收缩反应的变化显著高于血压正常者血浆存在时的变化（P＜0.03），而对氯化钾的收缩反应在两组之间无差异（P=无显著性差异）。这些发现提示，在高血压血浆存在的情况下，人体动脉血管反应性增加可能与需要受体介导激活血管平滑肌细胞的特定机制有关。
