Drózdz M, Kula B, Wardas M, Weglarz L
Department of Biochemistry and Chemistry, Medical University School of Silesia, Poland.
Biomed Biochim Acta. 1988;47(3):247-50.
A drug-induced collagen-like syndrome was produced in rats by hydralazine administration for 8, 9 and 10 months. The hyaluronic acid content and the hyaluronidase activity in liver and spleen were studied. A decrease in the hyaluronic acid amount was accompanied by an enhanced activity of hyaluronidase in both tissues. The results provide evidence for metabolic disturbances of glycosaminoglycans in the connective tissue in the collagen disease-like syndrome.
通过给予大鼠肼苯哒嗪8、9和10个月，诱导产生了药物性胶原样综合征。研究了肝脏和脾脏中的透明质酸含量及透明质酸酶活性。在这两种组织中，透明质酸量的减少伴随着透明质酸酶活性的增强。这些结果为胶原病样综合征中结缔组织中糖胺聚糖的代谢紊乱提供了证据。
