Serum glycoproteins level and urinary glycosaminoglycans excretion in drug induced collagen-like syndrome in guinea pigs.

A collagen-like syndrome was produced by a long-term administration of 1-hydrazinophthalazine (hydralazine) to guinea pigs. The results obtained indicate that hydralazine-induced collagen-like syndrome stimulated an increase of the concentration of perchloric acid-soluble proteins, protein-bound hexoses, protein-bound-hexosamines and sialic acids in blood serum as well as urinary excretion of glycosaminoglycans. The increase of serum glycoproteins is not connected with non-specific changes in total protein level. No biochemical differences were found in the parameters studied between subgroups (LE-positive and LE-negative) of hydralazine treated animals.