Nacchiero M, Biezunski D, Landau S, Dreiling D A, Adler M, Rudick J
Am J Gastroenterol. 1978 Oct;70(4):374-8.
Effects of a synthetic prostaglandin analog--16,16-dimethyl prostaglandin E2 methyl ester (16-diMe-PGE2)--on parotid secretion were evaluated in eight dogs under anesthesia. Graded doses of 16-diMe-PGE2 (0.3, 0.5, 1.0 and 2.5 microgram./kg.) were administered intravenously with the parotid in the resting state or in response to urecholine (intravenous infusion or subcutaneous injections). Profound and prolonged inhibition of volume occurred. Amylase concentration was increased but output was unchanged. Bicarbonate concentration was increased but output was decreased. Nonsteroid inhibitors of endogenous prostaglandin synthesis did not alter these effects. Although these studies do not establish a physiologic role for prostaglandins in the regulation of salivary secretion, they do demonstrate a wide-ranging effect of prostaglandins on the gastrointestinal tract.
在八只麻醉犬身上评估了一种合成前列腺素类似物——16,16 - 二甲基前列腺素E2甲酯（16 - 二甲基 - PGE2）对腮腺分泌的影响。在腮腺处于静息状态或对乌拉胆碱（静脉输注或皮下注射）产生反应时，静脉注射分级剂量的16 - 二甲基 - PGE2（0.3、0.5、1.0和2.5微克/千克）。出现了深度且持久的体积抑制。淀粉酶浓度升高但输出量未变。碳酸氢盐浓度升高但输出量降低。内源性前列腺素合成的非甾体抑制剂并未改变这些效应。尽管这些研究并未确立前列腺素在唾液分泌调节中的生理作用，但它们确实证明了前列腺素对胃肠道具有广泛的影响。
