Inga Allison, Griffeth Gregory C, Drobatz Kenneth J, Goldschmidt Kyle H, Mauldin Elizabeth A
Red Bank Veterinary Hospital, 197 Hance Ave, Tinton Falls, NJ, 07724, USA.
School of Veterinary Medicine, Department of Clinical Studies, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA, 19104, USA.
Vet Dermatol. 2020 Jun;31(3):219-e47. doi: 10.1111/vde.12820. Epub 2019 Dec 2.
It has long been speculated that sterile granulomatous dermatitis and lymphadenitis (SGDL) occurs in adult dogs. However, only three published case reports exist.
HYPOTHESIS/OBJECTIVES: To describe clinical presentation, identify breed predispositions, and assess treatment and outcomes of adult dogs with the histopathological diagnosis of SGDL.
Included are 90 dogs with biopsies submitted to a veterinary teaching hospital with a histopathological diagnosis consistent with SGDL, from 2004 to 2018, of which 35 had medical records available for review.
Data were analysed retrospectively from histopathology submission forms, medical records, surveys and telephone calls. Scoring systems were created to aid statistical analysis of outcomes.
Havanese dog (P < 0.0001), Australian shepherd dog (P < 0.0001), Irish setter (P < 0.0001), Dachshund (P = 0.0002), bichon frise (P = 0.0003) and Maltese dog (P = 0.004) were significantly over-represented breeds. The median age at onset was 1,292 days (3.54 years). Dogs up to five years of age were significantly over-represented (P < 0.01). Of 35 dogs with medical records available for review, the median treatment duration was 60 days and the median time to remission 28 days. Remission status was not established for five dogs but the remaining 30 dogs reached remission. Nineteen dogs remained in complete remission. Recrudescence occurred in 11 dogs (median follow-up 60 days).
This study shows a close parallel in clinical appearance, histopathological results and clinical behaviour, of both adult and juvenile onset SGDL; therefore, SGDL should be considered as a differential diagnosis for dogs of all ages.
长期以来一直推测成年犬会发生无菌性肉芽肿性皮炎和淋巴结炎（SGDL）。然而，仅有三篇已发表的病例报告。
假设/目的：描述成年犬经组织病理学诊断为SGDL的临床表现，确定品种易感性，并评估治疗方法和结果。
纳入2004年至2018年提交给一家兽医教学医院进行活检且组织病理学诊断与SGDL相符的90只犬，其中35只犬有可供查阅的病历。
从组织病理学提交表、病历、调查问卷和电话回访中进行回顾性数据分析。创建评分系统以辅助对结果进行统计分析。
哈瓦那犬（P < 0.0001）、澳大利亚牧羊犬（P < 0.0001）、爱尔兰雪达犬（P < 0.0001）、腊肠犬（P = 0.0002）、卷毛比雄犬（P = 0.0003）和马尔济斯犬（P = 0.004）是显著超比例代表品种。发病的中位年龄为1292天（3.54岁）。五岁及以下的犬显著超比例代表（P < 0.01）。在可供查阅病历的35只犬中，中位治疗持续时间为60天，中位缓解时间为28天。五只犬未确定缓解状态，但其余30只犬达到缓解。19只犬保持完全缓解。11只犬复发（中位随访60天）。
本研究表明成年和幼年发病的SGDL在临床外观、组织病理学结果和临床行为上非常相似；因此，SGDL应被视为所有年龄段犬的鉴别诊断。
