Ribas Latre A, McPartland A, Cain D, Walker D, Black V, Van Den Steen N, Warman S, Battersby I, Murtagh K, Silvestrini P, Batchelor D, Tappin S W
Dick White Referrals, Six Mile Bottom, Cambridgeshire, CB8 0UH, UK.
Davies Veterinary Specialists, Hitchin, Hertfordshire, SG5 3HR, UK.
J Small Anim Pract. 2019 May;60(5):280-290. doi: 10.1111/jsap.12980. Epub 2019 Jan 26.
To report clinical and laboratory features, treatment responses and outcome in dogs diagnosed with sterile steroid-responsive lymphadenitis in the United Kingdom.
Medical records of dogs diagnosed with sterile steroid-responsive lymphadenitis from 2009 to 2016 at six specialist referral centres were evaluated retrospectively.
The study included 49 dogs. Springer spaniels appeared to be over-represented (16 of 49 dogs). Young dogs (median age: 3 years and 9 months) and females (31 of 49) were frequently affected. Clinical presentation was variable, with pyrexia (39 of 49), lethargy (35 of 49) and anorexia (21 of 49) the most commonly reported clinical signs. Lymph node cytology or histopathology demonstrated neutrophilic, pyogranulomatous, granulomatous or necrotising lymphadenitis without a detectable underlying cause in all cases. Because a sterile immune-mediated aetiology was suspected, all dogs received prednisolone, which was followed by rapid resolution of clinical signs and lymphadenopathy in most cases.
Sterile steroid-responsive lymphadenitis should be considered in dogs with pyrexia of unknown origin with inflammatory lymphadenopathy if no underlying cause can be found and often responds well to immunosuppressive corticosteroid therapy.
报告在英国被诊断为无菌性类固醇反应性淋巴结炎的犬只的临床和实验室特征、治疗反应及预后情况。
对2009年至2016年期间在六个专科转诊中心被诊断为无菌性类固醇反应性淋巴结炎的犬只的病历进行回顾性评估。
该研究纳入了49只犬。史宾格犬的比例似乎过高（49只犬中有16只）。幼犬（中位年龄：3岁9个月）和雌性犬（49只中有31只）经常受到影响。临床表现各异，发热（49只中有39只）、嗜睡（49只中有35只）和厌食（49只中有21只）是最常报告的临床症状。所有病例的淋巴结细胞学或组织病理学检查均显示为中性粒细胞性、脓性肉芽肿性、肉芽肿性或坏死性淋巴结炎，且未发现可检测到的潜在病因。由于怀疑是无菌性免疫介导病因，所有犬只均接受了泼尼松龙治疗，大多数病例随后临床症状和淋巴结病迅速缓解。
对于不明原因发热且伴有炎性淋巴结病的犬只，如果未发现潜在病因，应考虑无菌性类固醇反应性淋巴结炎，且其通常对免疫抑制性皮质类固醇治疗反应良好。
