Chow Timothy G, Gill Michelle A
Department of Pediatrics.
Department of Internal Medicine.
Curr Opin Allergy Clin Immunol. 2020 Feb;20(1):56-63. doi: 10.1097/ACI.0000000000000603.
Dendritic cells are critical in directing inflammatory versus tolerogenic responses. As the burden of allergic disease rises worldwide, increased understanding of mechanisms underlying these diseases is needed. This review highlights research demonstrating how dendritic cells influence allergic disease development, providing important mechanistic insights into current clinical management strategies as well as potential areas of focus for future development of novel therapeutic strategies.
Recent studies continue to elucidate dendritic cell-associated pathways which can either promote or prevent allergic inflammation. Mechanisms involved include various aspects of dendritic cell activity, from antigen sampling and dendritic cell migration to complex dendritic cell interactions with other immune cells, infectious agents and allergens. A deeper understanding of these mechanisms and how dendritic cells promote tolerance provides insight into potential strategies to therapeutically target dendritic cells in the management of allergic disease.
Recent discoveries illustrate crucial roles of dendritic cells as regulators of inflammatory versus tolerant cascades. Building on lessons from oncologic strategies for harnessing dendritic cells to promote antitumor responses, several novel pathways could also be targeted to promote dendritic cell-mediated tolerogenesis in the context of allergy. Additional studies are needed to further define the roles and potential effects of dendritic cells in these potential strategies to reduce allergic inflammation.
树突状细胞在引导炎症反应与耐受反应方面至关重要。随着全球过敏性疾病负担的增加，需要进一步了解这些疾病的潜在机制。本综述重点介绍了有关树突状细胞如何影响过敏性疾病发展的研究，为当前临床管理策略提供了重要的机制见解，并为新型治疗策略的未来发展指明了潜在的重点领域。
近期研究不断阐明与树突状细胞相关的通路，这些通路既能促进也能预防过敏性炎症。涉及的机制包括树突状细胞活性的各个方面，从抗原摄取、树突状细胞迁移到树突状细胞与其他免疫细胞、病原体及过敏原之间复杂的相互作用。深入了解这些机制以及树突状细胞如何促进耐受性，有助于深入了解在过敏性疾病管理中针对树突状细胞进行治疗的潜在策略。
近期的发现表明树突状细胞作为炎症与耐受级联反应调节因子的关键作用。借鉴肿瘤学中利用树突状细胞促进抗肿瘤反应的策略，在过敏领域也可针对一些新的通路来促进树突状细胞介导的耐受性形成。还需要进一步的研究来明确树突状细胞在这些减少过敏性炎症的潜在策略中的作用和潜在影响。
