School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
Chem Biodivers. 2020 Jan;17(1):e1900600. doi: 10.1002/cbdv.201900600. Epub 2019 Dec 23.
Four new hetisine-type C -diterpenoid alkaloids, named as coreanines A-D (1-4), were isolated from the roots of Aconitum coreanum, together with thirteen known alkaloids (5-17). Their structures were elucidated by extensive spectroscopic methods including IR, HR-ESI-MS and NMR techniques. All the isolated compounds were screened for the acetylcholinesterase (AChE) inhibitory effects, and none of them showed considerable inhibitory activity.
从乌头属植物中分离得到了四个新的替比辛型 C-二萜生物碱，分别命名为朝鲜碱 A-D（1-4），此外还分离得到了 13 个已知生物碱（5-17）。通过红外光谱、高分辨电喷雾质谱和 NMR 等多种光谱方法鉴定了它们的结构。对所有分离得到的化合物进行了乙酰胆碱酯酶（AChE）抑制活性筛选，结果表明它们均没有明显的抑制活性。
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