Yang Hong-Bo, Luo Yan-Yan, Xu Jin-Bu, Liu Yue, Gao Feng, Huang Shuai, Chen Lin, Zhou Xian-Li
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
Chem Biodivers. 2022 Oct;19(10):e202200483. doi: 10.1002/cbdv.202200483. Epub 2022 Sep 26.
Two new lappaconitine-type C -diterpenoid alkaloids, named as leucostosines C (1) and D (2), together with six known compounds (3-8), were isolated from the roots of Aconitum leucostomum Worosch. Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, NMR spectra and X-ray experiments. Leucostosine C is the first diterpenoid alkaloid bearing the 7-amino group. The isolated compounds were tested for the acetylcholinesterase (AChE) inhibitory effect and neuroprotective activity, none of them showed significant activities.
从白喉乌头（Aconitum leucostomum Worosch）的根部分离得到了两种新的拉帕乌头碱型C-二萜生物碱，命名为白喉乌头碱C（1）和D（2），以及六种已知化合物（3-8）。通过包括红外光谱（IR）、高分辨电喷雾电离质谱（HR-ESI-MS）、核磁共振光谱（NMR）和X射线实验在内的各种光谱分析方法确定了它们的结构。白喉乌头碱C是首个带有7-氨基的二萜生物碱。对分离得到的化合物进行了乙酰胆碱酯酶（AChE）抑制作用和神经保护活性测试，结果表明它们均无显著活性。
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