Felicio L F, Miranda W L, Nasello A G
Departamento de Patologia, Faculdade de Medicina Veterinária, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1988;21(1):133-6.
The purpose of this study was to correlate behavioral modifications observed in perinatally bromopride-treated animals with possible changes in prolactin (PRL) serum levels. Adult male and female rats perinatally treated with bromopride during pregnancy and/or lactation were used for measuring PRL serum levels. There were no differences in hormone levels between experimental and control groups. The well known sexual dimorphism was observed, i.e. females showed higher levels of PRL than did males. Males of the same cage showed a hormone increase related to the sequence of sacrifice, i.e. the first animals to be sacrificed showed lower PRL levels than did subsequent ones. The possibility raised was that behavioral changes previously observed in rats treated perinatally with bromopride are not related to changes in PRL levels.
本研究的目的是将围产期用溴必利治疗的动物所观察到的行为改变与催乳素（PRL）血清水平的可能变化联系起来。使用在怀孕和/或哺乳期接受围产期溴必利治疗的成年雄性和雌性大鼠来测量PRL血清水平。实验组和对照组之间的激素水平没有差异。观察到了众所周知的性别二态性，即雌性的PRL水平高于雄性。同一笼中的雄性显示出与处死顺序相关的激素增加，即最先被处死的动物的PRL水平低于随后处死的动物。由此提出的可能性是，先前在围产期用溴必利治疗的大鼠中观察到的行为变化与PRL水平的变化无关。
