Fracasso J F, Rodrigues L A, Yashuda Y
Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP, Brasil.
Braz J Med Biol Res. 1988;21(1):31-3.
Fibrinolysis is a basic defense mechanism of the organism designed to control the deposition of fibrin in the vascular system and elsewhere. Fibrinolytic activity was measured by the fibrin plate method for three groups of rats (N = 6) that were maintained at room temperature, 20-25 degrees C, 3 degrees C or 38 degrees C for 4 h before testing. Based on measurement of fibrinolytic activity, the level of plasminogen activator released from isolated aortic segments of rats maintained at room temperature (24-28 degrees C) differed significantly from that of the 38 degrees C group. The animals maintained at 3 degrees C did not release plasminogen activator, suggesting that the fibrinolytic response was impaired at low temperature.
纤维蛋白溶解是机体的一种基本防御机制，旨在控制纤维蛋白在血管系统及其他部位的沉积。采用纤维蛋白平板法对三组大鼠（每组n = 6）的纤维蛋白溶解活性进行了测定，这三组大鼠在测试前分别于室温（20 - 25摄氏度）、3摄氏度或38摄氏度环境下饲养4小时。基于纤维蛋白溶解活性的测定结果，室温（24 - 28摄氏度）饲养的大鼠离体主动脉段释放的纤溶酶原激活物水平与38摄氏度组有显著差异。饲养于3摄氏度的动物未释放纤溶酶原激活物，这表明低温会损害纤维蛋白溶解反应。
