年龄与阿司匹林对大鼠的降压作用
Age and the antihypertensive effect of aspirin in rats.
作者信息
Tuttle R S, Yager J, Northrup N
机构信息
Masonic Medical Research Laboratory, Utica, NY 13501-1787.
出版信息
Br J Pharmacol. 1988 Jul;94(3):755-8. doi: 10.1111/j.1476-5381.1988.tb11585.x.
Abstract
- We previously showed that chronic exposure to aspirin (100 mg kg-1 daily, by mouth) is effective in preventing the onset of hypertension in young (28-84 day old) spontaneously hypertensive rats (SHRs). This is contrary to what others have reported using older SHRs. 2. Renal prostaglandin F2 alpha was also reduced in young SHRs and Wistar-Okamoto strain rats (WKYs) exposed to aspirin. 3. In the present study we extended the period of aspirin treatment in young rats to beyond 84 days of age. We found that aspirin lost its antihypertensive effect in SHR and WKY rats at 110 +/- 7 days of age regardless of whether the exposure to aspirin had begun at age 28, 49 or 87 days. 4. We conclude that the loss of antihypertensive effect of aspirin in the SHR and in older WKY rats, is determined by some factor(s) probably not related to prostaglandin F2 alpha, which reaches full expression in the 110 +/- 7 day old rat, or is fully dissipated at this age. 5. The anti-PGF2 alpha activity of aspirin in the SHR and WKY rat was short-lived and apparently unrelated in time to the antihypertensive effect of aspirin.
摘要
- 我们先前表明，长期给予阿司匹林（每日100毫克/千克，经口）可有效预防年轻（28 - 84日龄）自发性高血压大鼠（SHR）高血压的发生。这与其他人使用年龄较大的SHR所报告的结果相反。2. 在接触阿司匹林的年轻SHR和Wistar-Okamoto品系大鼠（WKY）中，肾前列腺素F2α也有所降低。3. 在本研究中，我们将年轻大鼠的阿司匹林治疗期延长至84日龄以上。我们发现，无论阿司匹林暴露是从28日龄、49日龄还是87日龄开始，在110±7日龄时，阿司匹林在SHR和WKY大鼠中均失去了其降压作用。4. 我们得出结论，阿司匹林在SHR和年龄较大的WKY大鼠中降压作用的丧失，是由一些可能与前列腺素F2α无关的因素决定的，前列腺素F2α在110±7日龄的大鼠中达到完全表达，或在这个年龄完全消散。5. 阿司匹林在SHR和WKY大鼠中的抗PGF2α活性是短暂的，且在时间上显然与阿司匹林的降压作用无关。
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