阿司匹林对血压自发升高和自发降低的自发性高血压大鼠（SHR）血压的不同影响。
Different effects of aspirin on blood pressure of spontaneously hypertensive rats (SHR) with high and spontaneously low levels of blood pressure.
作者信息
Schirner M, Taube C
机构信息
Institute of Pharmacology and Toxicology, Martin-Luther-University of Halle, Germany.
出版信息
Br J Pharmacol. 1993 Aug;109(4):900-1. doi: 10.1111/j.1476-5381.1993.tb13704.x.
Abstract
Spontaneously hypertensive rats (SHR) of the Okamoto strain with blood pressure above 161 mmHg and SHR with blood pressure levels of less than 160 mmHg were treated with oral doses of aspirin (100 mg kg-1) for three days. Whereas the blood pressure of SHR with blood pressure above 161 mmHg was decreased by aspirin, the blood pressure of SHR below 160 mmHg was increased by aspirin. The extent and direction of blood pressure change by aspirin was strongly correlated with the blood pressure of SHR before treatment (r = -0.88). The effect of aspirin supports an important role for endogenous prostanoids in the regulation of blood pressure of SHR.
摘要
对冈本品系血压高于161 mmHg的自发性高血压大鼠（SHR）和血压低于160 mmHg的SHR口服阿司匹林（100 mg/kg-1），持续三天。血压高于161 mmHg的SHR血压因阿司匹林而降低，而血压低于160 mmHg的SHR血压因阿司匹林而升高。阿司匹林引起的血压变化程度和方向与治疗前SHR的血压密切相关（r = -0.88）。阿司匹林的作用支持内源性前列腺素在SHR血压调节中起重要作用。
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