麻风瘤型麻风的血液学改变：一项横断面观察性研究。
Hematological alterations in lepromatous leprosy: A cross-sectional observational study.
机构信息
Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Department of Prosthetic Dental Science, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
出版信息
Dis Mon. 2020 Jul;66(7):100919. doi: 10.1016/j.disamonth.2019.100919. Epub 2019 Nov 30.
BACKGROUND
Dapsone has been the mainstay for the treatment of leprosy since its discovery in the 1940s. However, hematological disturbances are not uncommon in leprosy patients on daily dapsone therapy. Hence, the present study was conducted to document the hematologic alterations observed in lepromatous leprosy patients treated with Dapsone 100 mg daily.
METHODOLOGY
A cross-sectional observational study was conducted amongst 32 lepromatous leprosy patients treated with Dapsone 100 mg daily. A complete hemogram was conducted for all the study recruits. The test results were compared against the standard average values for adults for the given variables. The one sample t-test was employed to compare the difference between the study values and the standard normal values for adults. The statistical significance was considered at p < 0.05.
RESULTS
The study reveals a marked decrease in hemoglobin concentration in patients on dapsone, 100 mg daily. Other hematological alterations found were reduced platelet count, reduced mean platelet volume, reduced Hematocrit, reduced Mean Corpuscular hemoglobin, reduced Mean Corpuscular hemoglobin concentration. (p < 0.05).
CONCLUSION
Treatment of lepromatous leprosy with 100 mg daily Dapsone therapy may lead to hematological alterations. These findings are suggestive of dapsone-induced hemolysis.
背景
自 20 世纪 40 年代发现以来，氨苯砜一直是治疗麻风病的主要药物。然而，接受氨苯砜每日治疗的麻风病患者常出现血液系统紊乱。因此，本研究旨在记录接受氨苯砜 100mg 每日治疗的瘤型麻风病患者的血液学改变。
方法
对 32 例接受氨苯砜 100mg 每日治疗的瘤型麻风病患者进行了横断面观察性研究。对所有研究对象进行了全血细胞计数。将测试结果与成人的标准平均数值进行了比较。采用单样本 t 检验比较研究值与成人标准正态值之间的差异。统计学意义的标准为 p<0.05。
结果
研究表明，接受每日 100mg 氨苯砜治疗的患者血红蛋白浓度明显下降。其他发现的血液学改变包括血小板计数减少、平均血小板体积减少、血细胞比容减少、平均红细胞血红蛋白减少、平均红细胞血红蛋白浓度减少。（p<0.05）。
结论
用 100mg 每日氨苯砜治疗瘤型麻风病可能会导致血液学改变。这些发现提示氨苯砜诱导的溶血性贫血。
Zotero 插件