White P G, Podgorski M R, McLeod T I, Clarke A K
Royal National Hospital for Rheumatic Diseases, Bath.
Br J Rheumatol. 1988 Oct;27(5):399-402. doi: 10.1093/rheumatology/27.5.399.
A patient with definite polymyositis responded clinically to prednisolone in combination with azathioprine, with improvement in muscle strength and normalization of muscle enzyme levels. After 7 weeks' treatment the patient developed chest pain and fatal ventricular arrhythmias. An autopsy showed inflammatory myocarditis, but marked improvement in the skeletal muscle histology. This case illustrates that myocarditis may be a late complication of polymyositis despite immunosuppressive therapy.
一名确诊为多发性肌炎的患者在接受泼尼松龙联合硫唑嘌呤治疗后临床症状有所改善，肌肉力量增强，肌肉酶水平恢复正常。治疗7周后，该患者出现胸痛和致命性室性心律失常。尸检显示有炎性心肌炎，但骨骼肌组织学有明显改善。该病例表明，尽管进行了免疫抑制治疗，心肌炎仍可能是多发性肌炎的晚期并发症。
