胚胎中枢神经系统发育：神经发生、神经胶质发生、细胞命运和分化。
Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation.
机构信息
Department of Biochemistry and Biophysics, Integrative Program for Biological and Genome Sciences, School of Medicine, The University of North Carolina at Chapel Hill, North Carolina 27599.
出版信息
Genetics. 2019 Dec;213(4):1111-1144. doi: 10.1534/genetics.119.300974.
Abstract
The embryonic central nervous system (CNS) is a complex organ consisting of ∼15,000 neurons and glia that is generated in ∼1 day of development. For the past 40 years, developmental neuroscientists have described each step of CNS development in precise molecular genetic detail. This has led to an understanding of how an intricate nervous system emerges from a single cell. These studies have also provided important, new concepts in developmental biology, and provided an essential model for understanding similar processes in other organisms. In this article, the key genes that guide CNS development and how they function is reviewed. Features of CNS development covered in this review are neurogenesis, gliogenesis, cell fate specification, and differentiation.
摘要
胚胎中枢神经系统（CNS）是一个复杂的器官，由大约 15000 个神经元和神经胶质组成，大约在一天的发育过程中生成。在过去的 40 年里，发育神经科学家已经详细描述了 CNS 发育的每一个步骤的分子遗传细节。这使得人们了解到复杂的神经系统是如何从一个单细胞中产生的。这些研究还为发育生物学提供了重要的新概念，并为理解其他生物体中类似过程提供了一个重要的模型。在本文中，我们回顾了指导 CNS 发育的关键基因及其功能。本文综述了 CNS 发育的特征，包括神经发生、神经胶质发生、细胞命运特化和分化。
相似文献
1
Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation.胚胎中枢神经系统发育：神经发生、神经胶质发生、细胞命运和分化。
Genetics. 2019 Dec;213(4):1111-1144. doi: 10.1534/genetics.119.300974.
2
Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster.神经漫游者1和神经漫游者2在黑腹果蝇发育中的胚胎中枢神经系统中调节细胞命运特化。
Dev Biol. 2009 Jan 1;325(1):138-50. doi: 10.1016/j.ydbio.2008.10.006. Epub 2008 Nov 1.
3
Differential and redundant functions of gooseberry and gooseberry neuro in the central nervous system and segmentation of the Drosophila embryo.杨梅和杨梅神经在中枢神经系统中的差异和冗余功能及果蝇胚胎的分节。
Dev Biol. 2013 Oct 1;382(1):209-23. doi: 10.1016/j.ydbio.2013.05.017. Epub 2013 Jul 22.
4
Generating neuronal diversity in the Drosophila central nervous system.在果蝇中枢神经系统中产生神经元多样性。
Dev Dyn. 2012 Jan;241(1):57-68. doi: 10.1002/dvdy.22739. Epub 2011 Sep 19.
5
[Cell fate specification during lineage development in the Drosophila embryonic central nervous system].[果蝇胚胎中枢神经系统谱系发育过程中的细胞命运特化]
Tanpakushitsu Kakusan Koso. 2004 Feb;49(3 Suppl):228-33.
6
Rab11 is required for embryonic nervous system development in Drosophila.Rab11在果蝇胚胎神经系统发育中是必需的。
Cell Tissue Res. 2009 Feb;335(2):349-56. doi: 10.1007/s00441-008-0711-8. Epub 2008 Nov 18.
7
Glia development in the embryonic CNS of Drosophila.果蝇胚胎中枢神经系统中的神经胶质细胞发育。
Curr Opin Neurobiol. 1999 Oct;9(5):531-6. doi: 10.1016/S0959-4388(99)00008-2.
8
Programmed cell death in the embryonic central nervous system of Drosophila melanogaster.黑腹果蝇胚胎中枢神经系统中的程序性细胞死亡
Development. 2007 Jan;134(1):105-16. doi: 10.1242/dev.02707.
9
A common precursor for glia and neurons in the embryonic CNS of Drosophila gives rise to segment-specific lineage variants.果蝇胚胎中枢神经系统中神经胶质细胞和神经元的一种常见前体细胞会产生特定节段的谱系变体。
Development. 1993 Jul;118(3):765-75. doi: 10.1242/dev.118.3.765.
10
Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system.果蝇中枢神经系统细胞命运特化过程中，腹部 A 介导的细胞周期蛋白 E 表达抑制。
Mech Dev. 2010 Jan-Feb;127(1-2):137-45. doi: 10.1016/j.mod.2009.09.008. Epub 2009 Sep 30.
引用本文的文献
1
Resolving early embryonic metabolism in Drosophila through single-embryo metabolomics and transcriptomics.通过单胚胎代谢组学和转录组学解析果蝇早期胚胎代谢
Nat Metab. 2025 Aug 13. doi: 10.1038/s42255-025-01351-5.
2
Imp and Chinmo are required for embryonic motor neuron axon and dendrite targeting.胚胎运动神经元轴突和树突靶向需要Imp和Chinmo。
Biol Open. 2025 Jul 15;14(7). doi: 10.1242/bio.062105. Epub 2025 Jul 25.
3
The transcription factor CLAMP is required for neurogenesis in .转录因子CLAMP是[此处原文缺失具体部位]神经发生所必需的。
bioRxiv. 2025 Jul 7:2020.10.09.333831. doi: 10.1101/2020.10.09.333831.
4
Numb Suppresses Notch-Dependent Activation of during Lateral Inhibition in the Embryonic Nervous System.麻木抑制 Notch 依赖性激活 在胚胎神经系统中的侧向抑制。
Biomolecules. 2024 Aug 26;14(9):1062. doi: 10.3390/biom14091062.
5
Neurogenesis in Caenorhabditis elegans.秀丽隐杆线虫中的神经发生。
Genetics. 2024 Oct 7;228(2). doi: 10.1093/genetics/iyae116.
6
The astrocyte-enriched gene plays a crucial role in the development, locomotion, and lifespan of .富含星形胶质细胞的基因 在 的发育、运动和寿命中起着至关重要的作用。
Fly (Austin). 2024 Dec;18(1):2368336. doi: 10.1080/19336934.2024.2368336. Epub 2024 Jun 17.
7
A statistical method for quantifying progenitor cells reveals incipient cell fate commitments.一种用于量化祖细胞的统计方法揭示了初始的细胞命运决定。
Nat Methods. 2024 Apr;21(4):597-608. doi: 10.1038/s41592-024-02189-7. Epub 2024 Feb 20.
8
Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.昆虫发育中的 Notch 信号通路：一个具有多种功能的简单途径。
Int J Mol Sci. 2023 Sep 13;24(18):14028. doi: 10.3390/ijms241814028.
9
Ets-1 transcription factor regulates glial cell regeneration and function in planarians.Ets-1 转录因子调控涡虫中的神经胶质细胞再生和功能。
Development. 2023 Sep 15;150(18). doi: 10.1242/dev.201666.
10
Drosophila postembryonic nervous system development: a model for the endocrine control of development.果蝇胚胎后神经系统发育：内分泌发育调控的模型。
Genetics. 2023 Mar 2;223(3). doi: 10.1093/genetics/iyac184.
本文引用的文献
1
A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death.一个剪接体/黏合素轴改变染色质景观以促进神经母细胞死亡。
Development. 2019 May 1;146(9):dev166603. doi: 10.1242/dev.166603.
2
The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in .Hunchback 颞区转录因子决定. 运动神经元轴突和树突的靶向性。
Development. 2019 Apr 5;146(7):dev175570. doi: 10.1242/dev.175570.
3
A branching gene regulatory network dictating different aspects of a neuronal cell identity.一个分支的基因调控网络决定了神经元细胞身份的不同方面。
Development. 2019 Mar 15;146(6):dev174300. doi: 10.1242/dev.174300.
4
Brain expansion promoted by polycomb-mediated anterior enhancement of a neural stem cell proliferation program.多梳介导的神经干细胞增殖程序的前增强促进大脑扩张。
PLoS Biol. 2019 Feb 26;17(2):e3000163. doi: 10.1371/journal.pbio.3000163. eCollection 2019 Feb.
5
Mechanisms of Notch signaling: a simple logic deployed in time and space.Notch 信号通路的作用机制：在时间和空间中精确部署的简单逻辑。
Development. 2019 Feb 1;146(3):dev172148. doi: 10.1242/dev.172148.
6
Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.神经母细胞特异性开放染色质使瞬时转录因子 Hunchback 能够结合神经母细胞特异性基因座。
Elife. 2019 Jan 29;8:e44036. doi: 10.7554/eLife.44036.
7
A repressor-decay timer for robust temporal patterning in embryonic neuroblast lineages.一种用于胚胎神经母细胞谱系中稳健时间模式形成的阻遏物-衰减定时器。
Elife. 2018 Dec 10;7:e38631. doi: 10.7554/eLife.38631.
8
The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in and Preserves the Glial Fate.Repo Homeodomain 转录因子抑制 中的造血作用并维持神经胶质命运。
J Neurosci. 2019 Jan 9;39(2):238-255. doi: 10.1523/JNEUROSCI.1059-18.2018. Epub 2018 Nov 30.
9
Genetic variation in the locus is associated with erectile dysfunction.基因座的遗传变异与勃起功能障碍有关。
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11018-11023. doi: 10.1073/pnas.1809872115. Epub 2018 Oct 8.
10
The transcriptional factor Apt regulates neuroblast differentiation through activating CycE expression.转录因子 Apt 通过激活 CycE 表达调控神经母细胞瘤分化。
Biochem Biophys Res Commun. 2018 May 23;499(4):889-894. doi: 10.1016/j.bbrc.2018.04.012. Epub 2018 Apr 5.
Zotero 插件