胚胎中枢神经系统发育：神经发生、神经胶质发生、细胞命运和分化。
Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation.
机构信息
Department of Biochemistry and Biophysics, Integrative Program for Biological and Genome Sciences, School of Medicine, The University of North Carolina at Chapel Hill, North Carolina 27599.
出版信息
Genetics. 2019 Dec;213(4):1111-1144. doi: 10.1534/genetics.119.300974.
Abstract
The embryonic central nervous system (CNS) is a complex organ consisting of ∼15,000 neurons and glia that is generated in ∼1 day of development. For the past 40 years, developmental neuroscientists have described each step of CNS development in precise molecular genetic detail. This has led to an understanding of how an intricate nervous system emerges from a single cell. These studies have also provided important, new concepts in developmental biology, and provided an essential model for understanding similar processes in other organisms. In this article, the key genes that guide CNS development and how they function is reviewed. Features of CNS development covered in this review are neurogenesis, gliogenesis, cell fate specification, and differentiation.
摘要
胚胎中枢神经系统（CNS）是一个复杂的器官，由大约 15000 个神经元和神经胶质组成，大约在一天的发育过程中生成。在过去的 40 年里，发育神经科学家已经详细描述了 CNS 发育的每一个步骤的分子遗传细节。这使得人们了解到复杂的神经系统是如何从一个单细胞中产生的。这些研究还为发育生物学提供了重要的新概念，并为理解其他生物体中类似过程提供了一个重要的模型。在本文中，我们回顾了指导 CNS 发育的关键基因及其功能。本文综述了 CNS 发育的特征，包括神经发生、神经胶质发生、细胞命运特化和分化。
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