Nadeau S E
Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Gainesville, FL 32602.
Brain. 1988 Oct;111 ( Pt 5):1111-37. doi: 10.1093/brain/111.5.1111.
Extensive testing of grammatical function, including assessment of spontaneous language, inflectional morphology, ability to produce grammatical structures, syntactic comprehension and grammatical judgement, was carried out in 2 patients with large dominant frontal lobe lesions, including but not confined to, the third frontal convolution. Both patients were fluent and had normal articulation and phonological production and neither was agrammatic, suggesting that even very large frontal lesions do not produce Broca's aphasia and that language cortex proper is confined to the postcentral perisylvian region. Both patients were impaired in the use of more complex syntactic structures and one, who in addition had severe generalized impairment in frontal lobe function, also had impaired judgement regarding the use and placement of functors. These data provide further support for the dissociability of syntactic and morphological aspects of grammar in aphasic patients and, together with other studies, link these functions with the frontal lobe and the postcentral perisylvian cortex, respectively. The sparing of grammatical judgement in 1 patient, despite a very extensive lesion, suggests that very large portions of the frontal lobe are involved in grammatical function. The nature of frontal lobe function in syntax appears to be congruent with the role of the frontal lobes in other aspects of behaviour.
对2例优势额叶大面积病变患者（包括但不限于额下回）进行了广泛的语法功能测试，包括对自发语言、屈折形态学、语法结构生成能力、句法理解和语法判断的评估。两名患者语言流畅，发音和语音产生正常，均无语法缺失，这表明即使是非常大面积的额叶病变也不会导致布罗卡失语症，而且真正的语言皮层局限于中央后回周围的颞叶区域。两名患者在使用更复杂的句法结构方面均有障碍，其中一名患者除额叶功能严重普遍受损外，在功能词的使用和位置判断方面也有障碍。这些数据进一步支持了失语症患者语法的句法和形态方面的可分离性，并与其他研究一起，分别将这些功能与额叶和中央后回周围皮层联系起来。尽管有一名患者的病变范围非常广泛，但语法判断功能未受影响，这表明额叶的很大一部分参与了语法功能。额叶在句法中的功能性质似乎与额叶在其他行为方面的作用一致。
