重复经颅磁刺激对局限性书写痉挛行为和肌电图参数的急性及累积效应

Acute and cumulative effects of rTMS on behavioural and EMG parameters in Focal Hand Dystonia.

作者信息

Salatino Adriana, Boccia Gennaro, Dardanello Davide, Formicola Donato, Spadea Giulia, Nobili Marcello, Berti Anna

机构信息

Department of Psychology, University of Turin, Via Po 14, 10123, Italy.

NeuroMuscularFunction Research Group, Department of Medical Sciences, University of Turin. 12, piazza Bernini, 10143, Torino, Italy.

出版信息

Heliyon. 2019 Nov 22;5(11):e02770. doi: 10.1016/j.heliyon.2019.e02770. eCollection 2019 Nov.

DOI:10.1016/j.heliyon.2019.e02770

PMID:31799459

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6881623/

Abstract

Previous studies suggest that low-frequency repetitive Transcranial Magnetic Stimulation (rTMS) over contralateral premotor cortex (PMC) might ameliorate Focal Hand Dystonia (FHD) symptoms. In the present study behavioral and muscle activity outcomes were explored in a patient with FHD following a single and multiple sessions of rTMS. The patient's behavior was assessed on handwriting tasks, while surface EMG signals were recorded. In Experiment 1 evaluations were performed before and after one session of active and sham 1Hz rTMS over contralateral PMC. In Experiment 2, evaluations were performed before and after six sessions of the same treatment. In Experiment 1 active rTMS improved the patient's performance, although the EMG amplitude did not change. In Experiment 2, the patient showed an improvement of performance along with a decrease of 20% in the EMG amplitude. These results demonstrated that a single session of rTMS ameliorated the patient's performance, while multiple sessions were necessary to reduce muscles activity.

摘要

先前的研究表明，对侧运动前区皮质（PMC）的低频重复经颅磁刺激（rTMS）可能会改善局灶性手部肌张力障碍（FHD）症状。在本研究中，对一名FHD患者在接受单次和多次rTMS治疗后的行为和肌肉活动结果进行了探究。通过手写任务评估患者的行为，同时记录表面肌电图信号。在实验1中，在对侧PMC进行一次主动和假1Hz rTMS治疗前后进行评估。在实验2中，在进行六次相同治疗前后进行评估。在实验1中，主动rTMS改善了患者的表现，尽管肌电图幅度没有变化。在实验2中，患者的表现有所改善，同时肌电图幅度降低了20%。这些结果表明，单次rTMS治疗改善了患者的表现，而需要多次治疗才能降低肌肉活动。