Landolfi R, Colosimo C, De Candia E, Castellana M A, De Cristofaro R, Trodella L, Leone G
Department of Hematology, Catholic University, Rome, Italy.
Cancer. 1988 Dec 1;62(11):2346-9. doi: 10.1002/1097-0142(19881201)62:11<2346::aid-cncr2820621115>3.0.co;2-e.
Meningeal myeloid metaplasia (MM) is very rarely observed in patients with myelofibrosis. We report the occurrence of meningeal MM causing exophthalmus and fever in a patient with myelofibrosis secondary to polycythemia vera. A computerized tomography (CT) scan showed multiple intracranial and intraorbital enhancing masses. A needle aspirate of retrobulbar space confirmed the diagnosis of extramedullary hematopoiesis. The patient subsequently developed a rapidly worsening tumor-like syndrome with hemiparesis, aphasia, and loss of sphinteric control. The administration of radiotherapy caused a complete and stable regression of clinical symptoms and a marked reduction of MM masses.
脑膜髓样化生（MM）在骨髓纤维化患者中极为罕见。我们报告了一例真性红细胞增多症继发骨髓纤维化患者发生脑膜MM并导致眼球突出和发热的病例。计算机断层扫描（CT）显示颅内和眶内有多个强化肿块。球后间隙穿刺抽吸确诊为髓外造血。该患者随后出现了迅速恶化的肿瘤样综合征，伴有偏瘫、失语和括约肌控制丧失。放疗后临床症状完全且稳定缓解，MM肿块明显缩小。
